Psychiatric Quarterly

, Volume 73, Issue 2, pp 123–133 | Cite as

Clinical Relevance of Biologic Findings in PTSD

  • Rachel Yehuda


Posttraumatic stress disorder (PTSD) describes a syndrome in which a trauma survivor experiences an inability to get the event out of his/her mind. The symptoms of PTSD were initially conceptualized as resulting from the cascade of biological and psychological responses following the activation of fear and other brain systems. In the last decade, scientific developments have led to a better understanding of why only certain individuals develop this disorder. Furthermore, studies of the neurobiology of PTSD have delineated specific alterations that help shape our understanding of how biological and psychological responses at the time of traumatic events may have long-term consequences. This review will discuss these new findings and their treatment implications.

posttraumatic stress disorder (PTSD) neurobiology fear cortisol risk factors treatment 


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Copyright information

© Human Sciences Press, Inc. 2002

Authors and Affiliations

  • Rachel Yehuda
    • 1
  1. 1.Department of PsychiatryMount Sinai School of Medicine, Bronx Veterans AffairsNew York

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