Cancer Causes & Control

, Volume 13, Issue 3, pp 249–254 | Cite as

A prospective cohort study of cigarette smoking and pancreatic cancer in Japan

  • Yingsong Lin
  • Akiko Tamakoshi
  • Takashi Kawamura
  • Yutaka Inaba
  • Shogo Kikuchi
  • Yutaka Motohashi
  • Michiko Kurosawa
  • Yoshiyuki Ohno


Objective: To examine the association of cigarette smoking with the risk of death from pancreatic cancer in a prospective cohort study. Methods: A total of 110,792 inhabitants, aged 40–79 years (46,465 men and 64,327 women), were enrolled from 1988 to 1990 and followed up for mortality to the end of 1997. At baseline a self-administered questionnaire was used to obtain information on cigarette smoking and other lifestyle factors. Results: During the follow-up period (mean ± SD: 8.1 ± 1.8 years), 225 deaths due to pancreatic cancer were identified. After adjustment for age, body mass index, history of diabetes mellitus, and gallbladder diseases, the relative risks (RRs) for current smokers were 1.6 (95% CI 0.95–2.6) in males, and 1.7 (95% CI: 0.84–3.3) in females. Men who smoked more than 40 cigarettes per day had a substantially higher risk of pancreatic cancer, with a RR of 3.3 (95% CI: 1.4–8.1). A significantly decreasing trend in risk with increasing years after smoking cessation was observed (trend p = 0.04) among male ex-smokers. The RRs were 0.85 (95% CI 0.36–2.0) and 0.85 (0.36–2.0) for those who had quit smoking for 10–19 and ≥20 years, respectively. Conclusions: Our cohort study confirmed that cigarette smoking was associated with an increased risk of death from pancreatic cancer.

cigarette smoking cohort study Japan pancreatic cancer 


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Copyright information

© Kluwer Academic Publishers 2002

Authors and Affiliations

  • Yingsong Lin
    • 1
    • 2
  • Akiko Tamakoshi
    • 3
  • Takashi Kawamura
    • 4
  • Yutaka Inaba
    • 5
  • Shogo Kikuchi
    • 1
  • Yutaka Motohashi
    • 6
  • Michiko Kurosawa
    • 5
  • Yoshiyuki Ohno
    • 2
  1. 1.Department of Public HealthAichi Medical University School of MedicineAichi PrefectureJapan
  2. 2.Department of Preventive Medicine/Biostatistics and Medical Decision makingNagoya University Graduate School of MedicineNagoyaJapan
  3. 3.Department of Preventive Medicine/Biostatistics and Medical Decision MakingNagoya University Graduate School of MedicineShowa-ku, Nagoya
  4. 4.Kyoto University Center for Student HealthKyotoJapan
  5. 5.Department of Epidemiology and Environmental HealthJuentendo University School of MedicineTokyoJapan
  6. 6.Department of Public HealthAkita University School of MedicineAkitaJapan

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