Digestive Diseases and Sciences

, Volume 47, Issue 5, pp 1080–1085 | Cite as

Implication of Anti-Parietal Cell Antibody Levels in Gastrointestinal Diseases, Including Gastric Carcinogenesis

  • Masanori Ito
  • Ken Haruma
  • Shunji Kaya
  • Hirohisa Kai
  • Hiroshi Masuda
  • Masahiro Ohta
  • Masaharu Sumii
  • Shinji Tanaka
  • Masaharu Yoshihara
  • Kazuaki Chayama


We investigated serum levels of anti-parietal cell antibody (APCA) in relation to various gastric diseases. Subjects were 224 Japanese patients including 58 with gastric cancer. All patients underwent gastroscopy, and APCA was investigated by enzyme-linked immunosorbent assay. Unexpectedly, there was no difference in APCA levels between patients with gastric cancer and those with gastritis. Among H. pylori-positive patients, APCA levels were closely correlated with grades of atrophy when no gastric cancer was present, but no correlation was found when gastric cancer was present. APCA-negative gastric cancer was found mainly in males and was characterized by massive infiltration of neutrophils in the background mucosa. The 24 patients with gastric cancer were APCA-negative and showed low pepsinogen levels. The odds ratio for the incidence of gastric cancer in these patients was 7.90 (95% CI 3.4–18.4). This suggests APCA-negative gastric cancer is the predominant form of gastric cancer in Japan.

anti-parietal cell antibody gastric cancer Helicobacter pylori atrophic gastritis 


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Copyright information

© Plenum Publishing Corporation 2002

Authors and Affiliations

  • Masanori Ito
    • 1
    • 2
  • Ken Haruma
    • 2
  • Shunji Kaya
    • 3
  • Hirohisa Kai
    • 4
  • Hiroshi Masuda
    • 4
  • Masahiro Ohta
    • 4
  • Masaharu Sumii
    • 4
  • Shinji Tanaka
    • 4
  • Masaharu Yoshihara
    • 5
  • Kazuaki Chayama
    • 4
  1. 1.First Department of Internal MedicineHiroshima University School of MedicineHiroshimaJapan
  2. 2.Health Service CenterHiroshima UniversityHiroshimaJapan
  3. 3.Biological Chemistry, Graduate School of ScienceHokkaido UniversitySapporoJapan
  4. 4.First Department of Internal MedicineHiroshima University School of MedicineHiroshimaJapan
  5. 5.Health Service CenterHiroshima UniversityHiroshimaJapan

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