Glycoconjugate Journal

, Volume 18, Issue 5, pp 373–390

N- and O-linked oligosaccharides of allergenic glycoproteins

  • Kay Fötisch
  • Stefan Vieths*
Article

DOI: 10.1023/A:1014860030380

Cite this article as:
Fötisch, K. & Vieths*, S. Glycoconj J (2001) 18: 373. doi:10.1023/A:1014860030380

Abstract

Cross-linking of cell-bound IgE on mast cells or basophils by polyvalent antigens causes the release of histamine and other mediators of the allergic response which then lead to the development of allergic symptoms. In this event not only peptide epitopes, but also carbohydrates can act as cross-linking elements. Since peptide epitopes of allergens are subject of most published studies, this review is focused on glycosidic epitopes. The current knowledge of the structures and possible epitopes of oligosaccharides linked to allergenic glycoproteins is briefly reviewed, showing that complex plant N-glycans containing α1,3 fucose and β1,2 xylose are most frequently involved in the structures of IgE epitopes. In own studies a prevalence of up to 29% anti-glycan IgE was determined among pollen-allergic patients. The clinical relevance of these carbohydrate specific IgE antibodies is still a matter of controversial discussions.

CCD IgE reactivity epitope prevalence clinical relevance 

Copyright information

© Kluwer Academic Publishers 2001

Authors and Affiliations

  • Kay Fötisch
    • 1
  • Stefan Vieths*
    • 1
  1. 1.Department of AllergologyPaul-Ehrlich-InstitutLangenGermany

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