Skip to main content
Log in

CASE REPORT: Light Chain Deposition Disease of the Liver Without Renal Involvement in a Patient with Multiple Myeloma Related to Liver Failure and Rapid Fatal Outcome

  • Published:
Digestive Diseases and Sciences Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

REFERENCES

  1. Buxbaum JN, Chuba JV, Hellmann GC, Solomon A, Gallo GR: Monoclonal immunoglobulin deposition disease: Light chain and light and heavy chain deposition disease and their relation to light chain amyloidosis. Ann Intern Med 112:455–464, 1990

    PubMed  Google Scholar 

  2. Randall RE, Williamson WC, Mullinax F, Tung MY, Still WJS: Manifestations of systemic light deposition. Am J Med 60:293–299, 1976

    PubMed  Google Scholar 

  3. Confalonieri R, Barbiano di Belgioioso G, Banfi G, Ferrario F, Bertani T, Pozzi C, Casanova S, Lupo A, De Ferrari G, Minetti: Light chain nephropathy: histological and clinical aspects in 15 cases. Nephrol Dial Tranplant 3:150–156, 1988

    Google Scholar 

  4. Maury CPJ, Teppo AM: Massive cutaneous hyalinosis. Identification of the hyalin material as monoclonal kappa light chains, adhesive 90 kD glycoprotein, and type I collagen. Am J Clin Pathol 82:543–551, 1984

    PubMed  Google Scholar 

  5. Kijner CH, Yousem SY: Systemic light chain deposition disease presenting as pulmonary nodules. Am J Surg Pathol 12:405–413, 1988

    PubMed  Google Scholar 

  6. Stone GC, Wall BA, Oppliger IR, Wener MH, Jolly SL, Aguirre A, Dwyer R, Simkin PA: A vasculopathy with deposition of lambda light chain crystals. Ann Intern Med 110:275–278, 1989

    PubMed  Google Scholar 

  7. Droz D, Noel LH, Carnot F, Degos F, Ganeval D, Grunfeld JP: Liver involvement in non-amyloid light chain deposits disease. Lab Invest 50:683–689, 1984

    PubMed  Google Scholar 

  8. Bedossa P, Febre M, Paraf F, Martin E, Lemaigre G: Light chain deposition disease with liver dysfunction. Hum Pathol 19:1008–1014, 1988

    PubMed  Google Scholar 

  9. Le Verger JC, Toulet R, Deugnier Y, Ramie MP: Anomalies biologiques hépatiques au cours d'une maladie de chaines légères. Gastroenterol Clin Biol 9:184–185, 1985

    PubMed  Google Scholar 

  10. Preud'homme JL, Morel-Maroger L, Brouet JC, Mihaesco E, Mery JP, Seligmann PM: Synthesis of abnormal heavy and light chains in multiple myeloma with visceral deposition of monoclonal immunoglobulin. Clin Exp Immunol 42:545–553, 1980

    PubMed  Google Scholar 

  11. Hoffman-Guilaine C, Nochy D, Tricottet V, Mallet L, Bariety J, Camilleri JP: La maladie des dépôts de chaines légères. Une entité anatomopathologique. Ann Pathol 4:105–113, 1984

    PubMed  Google Scholar 

  12. Mallet L, Blosch F, Penalba C, Cerf M, Petite JP, Morel-Maroger L, Camilleri JP, Feldman G: Lésions hépatiques dans la maladie de chaines légères: 2 observations. Gastroenterol Clin Biol 6:3A, 1982 (abstract).

    Google Scholar 

  13. Faa G, Van Eyken P, De Vos R, Fevery J; Van Damme B; De Groote J, Desmet VJ: Light chain deposition disease of the liver associated with AL-type amyloidosis and severe cholestasis. A case report and literature review. J Hepatol 12:75–82, 1991

    PubMed  Google Scholar 

  14. Gireli C, Giovanni L, Rocca F: Light chain deposition disease of the liver. Eur J Gastroenterol Hepatol 10:429–430, 1999

    Google Scholar 

  15. Pelletier G, Fabre M, Attali P, Ladouch-Badre A, Ink O, Martin E, Etienne J-P: Light chain deposition disease with hepatomegaly: An association with amyloid-like fibrils. Postgrad Med J 64:804–808, 1988

    PubMed  Google Scholar 

  16. Kramlichi AA, Rocca A, Touchard G, Aucouturier P, Preud'homme JL, Cogne: Role of light chain variable region in myeloma with light chain deposition disease: Evidence from an experimental model. Blood 86:3655–3659, 1995

    PubMed  Google Scholar 

  17. Ganeval D, Noel LH, Droz D, Leibowitch J. Systemic lambda light chain deposition in a patient with myeloma. Br Med J 282:681–683, 1981

    Google Scholar 

  18. Feiner HD: Pathology of dysproteinemia: Light chain amyloidosis, non-amyloid immunoglobulin deposition disease, cryoglobulinemia syndromes and macroglobulinemia of Waldenstrom. Hum Pathol 19:1255–1272, 1988

    PubMed  Google Scholar 

  19. Finkelstein SD, Fornasier VL, Pruzanski W: Intrahepatic cholestasis with prominent pericentral deposition in systemic amyloidosis. Hum Pathol 12:470–472, 1981

    PubMed  Google Scholar 

  20. Alpers CD, Hopper J, Biava CG: Light chain glomerulopathy with amyloid-like deposits. Hum Pathol 15:444–448, 1984

    PubMed  Google Scholar 

  21. Gallo G, Picken MM, Frangione B, Buxbaum J: Nonamyloidotic monoclonal immunoglobulin deposits lack amyloid P component. Mod Pathol 1:453–456, 1988

    PubMed  Google Scholar 

  22. Kirkpatrick CJ, Curry A, Galle J, Melzner I: Systemic kappa light chain deposition and amyloidosis in multiple myeloma: Novel morphological observations. Histopathology 10:1065–1076, 1986

    PubMed  Google Scholar 

  23. Jacquot C, Saint-Andre JP, Touchard G, Nochy D, D'Auzac de Lamartinie C, Oriol R, et al: Association of systemic light chain deposition and amyloidosis: A report of three patients with renal involvement. Clin Nephrol 24:93–98, 1985

    PubMed  Google Scholar 

  24. Smith NM, Malcom AJ: Simultaneous AL-type amyloid and light chain deposit disease in a liver biopsy: A case report. Histopathology 10:1057–1064, 1986

    PubMed  Google Scholar 

  25. Silver MM, Hearn SA, Ritchie, et al: Renal and systemic kappa light chain deposits and their plasma cell origin identified by immunoelectron microscopy. Am J Pathol 122:17–27, 1986

    PubMed  Google Scholar 

  26. Mignon F, Morel-Maroger L, Cerf M, Preud'homme JL, Richet G: Dépôts hépatiques et renaux de chaines légères kappa révelateurs d'une dysglobulinemie. Nephrologie 1:167–170, 1980

    PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Michopoulos, S., Petraki, K., Petraki, C. et al. CASE REPORT: Light Chain Deposition Disease of the Liver Without Renal Involvement in a Patient with Multiple Myeloma Related to Liver Failure and Rapid Fatal Outcome. Dig Dis Sci 47, 730–734 (2002). https://doi.org/10.1023/A:1014773512707

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1023/A:1014773512707

Navigation