Digestive Diseases and Sciences

, Volume 47, Issue 4, pp 856–861 | Cite as

Melatonin Prevents Ethanol-Induced Gastric Mucosal Damage Possibly Due to Its Antioxidant Effect

  • Dilek Bilici
  • Halis Süleyman
  • Z. Nur Banoğlu
  • Ahmet Kiziltunç
  • Bahattin Avci
  • Akif Çiftçioğlu
  • Sefa Bilici


Oxygen radical release has been proposed as a pathogenic factor of the ethanol-induced acute gastric injury. Melatonin, a pineal hormone, is known to scavenge oxygen free radicals. We investigated whether parenteral administration of melatonin prevented ethanol-induced macroscopic damage, polymorphonuclear (PMN) leukocyte infiltration, depletion of total glutathione (tGSH) concentration, and glutathione reductase (GSSG-Rd) activity in the rat gastric mucosa. We compared the effects of melatonin with those of omeprazole. Ethanol-induced mucosal damage was evaluated using three different parameters: gastric total glutathione (tGSH) concentration and glutathione reductase (GSSG-Rd) activity, the number of PMN leukocytes, and macroscopic investigation. Gatric tGSH concentration and GSSG-Rd activity decreased and the number of PMNs increased after ethanol administration. It was found that pretreatment with melatonin increased both tGSH concentration and GSSG-Rd activity. Melatonin also reduced ethanol-induced PMN infiltration in the stomach. Ethanol administration damaged the entire gastric mucosa. Melatonin significantly decreased the extent of ethanol-induced macroscopic injury. In conclusion, these findings support the conclusion that the protection conferred by melatonin in gastric ulcer is presumably due to its antioxidant activity.

free radicals melatonin rat stomach tGSH GSSG-Rd 


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Copyright information

© Plenum Publishing Corporation 2002

Authors and Affiliations

  • Dilek Bilici
    • 1
  • Halis Süleyman
    • 2
  • Z. Nur Banoğlu
    • 2
  • Ahmet Kiziltunç
    • 3
  • Bahattin Avci
    • 3
  • Akif Çiftçioğlu
    • 4
  • Sefa Bilici
    • 5
  1. 1.Department of PharmacologyAtatürk Üniversitesi Tip Fakültesi, Farmakoloji anabilim daliErzurumTurkey
  2. 2.Department of Pharmacology, Medical SchoolAtatürk UniversityErzurumTurkey
  3. 3.Department of Biochemistry, Medical SchoolAtatürk UniversityErzurumTurkey
  4. 4.Department of Pathology, Medical SchoolAtatürk UniversityErzurumTurkey
  5. 5.Numune HospitalErzurumTurkey

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