Biomedical Microdevices

, Volume 4, Issue 2, pp 117–121 | Cite as

Microfluidics Section: Design and Fabrication of Integrated Passive Valves and Pumps for Flexible Polymer 3-Dimensional Microfluidic Systems

  • Noo Li Jeon
  • Daniel T. Chiu
  • Christopher J. Wargo
  • Hongkai Wu
  • Insung S. Choi
  • Janelle R. Anderson
  • George M. Whitesides
Article

Abstract

This paper describes the fabrication of flexible, polymeric 3-dimensional microfluidic systems with integrated check valves (flap and diaphragm valves) and a pump by stacking patterned poly(dimethylsiloxane) (PDMS) layers containing microchannels and vias. We describe this procedure for fabricating, manipulating, and bonding of PDMS membranes and bas-relief plates into multilayer microfluidic devices. The fabrication and demonstration of integrated check valves and a pump in a prototype polymer 3-dimensional microfluidic system is a step toward practical realization of all-polymer, flexible, low-cost, disposable microfluidic devices for biochemical applications.

microfluidics valves PDMS 

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Copyright information

© Kluwer Academic Publishers 2002

Authors and Affiliations

  • Noo Li Jeon
    • 1
  • Daniel T. Chiu
    • 1
  • Christopher J. Wargo
    • 1
  • Hongkai Wu
    • 1
  • Insung S. Choi
    • 1
  • Janelle R. Anderson
    • 1
  • George M. Whitesides
    • 1
  1. 1.Department of Chemistry and Chemical BiologyHarvard UniversityCambridge

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