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Biotechnology Letters

, Volume 24, Issue 6, pp 463–467 | Cite as

Microarray analysis of piceatannol-induced changes in gene expression in human gastric cancer cells

  • Dooil Jeoung
  • Seong-Jun Oh
  • Seongeun Lee
  • Myungin Baek
  • Youn-Hyung Lee
  • Nam-In Baek
  • Hae-Yeong Kim
Article

Abstract

Piceatannol, isolated from the roots of Rheum undulatum, prevented oxygen radical formation and inhibited lipid peroxidation; the effective concentrations were 25 μM for a radical scavenging assay and 2.1 μM for a microsome assay. Using cDNA microarray analysis to determine which genes were modulated by piceatannol, 33 genes were up-regulated while 157 genes were down-regulated in the human gastric cancer cell line.

antioxidant microarray piceatannol Rheum undulatum L. RT-PCR 

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Copyright information

© Kluwer Academic Publishers 2002

Authors and Affiliations

  • Dooil Jeoung
    • 1
  • Seong-Jun Oh
    • 2
  • Seongeun Lee
    • 1
  • Myungin Baek
    • 1
  • Youn-Hyung Lee
    • 2
  • Nam-In Baek
    • 2
  • Hae-Yeong Kim
    • 2
  1. 1.Cancer Genomics UnitIn2gen CompanySeoulKorea
  2. 2.Graduate School of Biotechnology and Plant Metabolism Research CenterKyung Hee UniversitySuwonKorea

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