Cancer Causes & Control

, Volume 12, Issue 10, pp 959–964 | Cite as

Intrahepatic cholangiocarcinoma and hepatitis C and B virus infection, alcohol intake, and hepatolithiasis: a case–control study in Italy

  • Francesco Donato
  • Umberto Gelatti
  • Alessandro Tagger
  • Maurizio Favret
  • Maria Lisa Ribero
  • Francesco Callea
  • Claudia Martelli
  • Antonella Savio
  • Paola Trevisi
  • Giuseppe Nardi


Objective: Intrahepatic cholangiocarcinoma (ICC) is a rare type of primary liver cancer (PLC) arising from intrahepatic bile ducts. We carried out a case–control study to assess the association between ICC and hepatitis B and C virus (HBV and HCV) infections, alcohol intake, and hepatolithiasis in Brescia, North Italy. Methods: Among 370 subjects with histology-based diagnosis of PLC who were resident in the area and hospitalized in 1995–2000, 26 (7%) ICC cases were identified. A total of 824 subjects unaffected by hepatic diseases and frequency-matched with PLC cases by age, sex, date, and hospital of admission were recruited as controls. Results: Among ICC cases the mean age was 65 years, 80.8% were males, and 38.5% had cirrhosis. Seropositivity for anti-HCV, HBsAg, alcohol intake > 80 g/day and history of hepatolithiasis were found in 25%, 13%, 23.1%, and 26.9% of ICC cases and in 5.8%, 6.7%, 32.9%, and 10.6% of controls, respectively. The odds ratios adjusted for demographic factors by logistic regression (95% confidence interval; 95% CI) were 9.7 (1.6–58.9) for anti-HCV, 2.7 (0.4–18.4) for HBsAg, and 6.7 (1.3–33.4) for hepatolithiasis, whereas no association was found with alcohol drinking. Conclusions: HCV and hepatolithiasis may be risk factors for ICC in Western countries.

hepatitis B virus hepatitis C virus hepatolithiasis intrahepatic cholangiocarcinoma 


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Copyright information

© Kluwer Academic Publishers 2001

Authors and Affiliations

  • Francesco Donato
    • 1
  • Umberto Gelatti
  • Alessandro Tagger
    • 2
  • Maurizio Favret
    • 3
  • Maria Lisa Ribero
    • 4
  • Francesco Callea
    • 5
  • Claudia Martelli
  • Antonella Savio
    • 6
  • Paola Trevisi
  • Giuseppe Nardi
  1. 1.Cattedra di IgieneUniversità di BresciaItaly
  2. 2.Istituto di VirologiaUniversità di MilanoItaly
  3. 3.Cattedra di Anatomia PatologicaUniversità di BresciaItaly
  4. 4.Istituto d'IgieneUniversità di MilanoItaly
  5. 5.Servizio di Anatomia Patologica I Spedali Civili di BresciaItaly
  6. 6.Servizio di Anatomia Patologica Ospedale S. OrsolaBresciaItaly

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