Biochemistry (Moscow)

, Volume 66, Issue 12, pp 1335–1341 | Cite as

Mitochondria Enter the Nucleus (One Further Problem in Chronic Alcoholism)

  • L. E. Bakeeva
  • V. P. Skulachev
  • Yu. V. Sudarikova
  • V. G. Tsyplenkova

Abstract

Electron microscopy of cardiomyocytes of patients with hypertrophic and alcoholic cardiomyopathies revealed the presence of nuclei with mitochondria accumulated in their core. This was associated with chromatin displacement towards the core of the nucleus. No large-scale intermixing of the nuclear content with the cytosol was found, although in some sections there were disruptions in the nuclear envelop continuity. The entrance of mitochondria into the nucleus was modeled in rats that were given ethanol and the catalase inhibitor aminotriazole for 12 weeks. It is suggested that the entrance of mitochondria into the nucleus promotes both the attack of mitochondria by nuclear proteins and the attack of nuclear DNA and proteins by proteins of the mitochondrial intermembrane space.

mitochondria nucleus alcoholic cardiomyopathy electron microscopy 

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REFERENCES

  1. 1.
    Hoffman, H., and Grigg, G. W. (1958) Exp. Cell Res., 15, 118–131.PubMedGoogle Scholar
  2. 2.
    Mori, H. (1960) Fukushima J. Med. Sci., 7, 21–32.Google Scholar
  3. 3.
    Brandes, D., Schonfield, B. H., and Antom, E. (1965) Science, 149, 1373–1374.PubMedGoogle Scholar
  4. 4.
    Klug, H. (1966) Naturwissenschaften, 53, 339.PubMedGoogle Scholar
  5. 5.
    Bloom, G. D. (1967) J. Cell Biol., 35, 266–268.PubMedGoogle Scholar
  6. 6.
    Oliva, H., Valle, A., Diaz Flores, L., and Rivas, M. C. (1973) Virchows Arch. Abt. B. Zellpath., 12, 189–194.Google Scholar
  7. 7.
    Schumacher, H. R., Szekely, I. E., Patel, S. B., and Fisher, D. R. (1974) Am. J. Pathol., 74, 71–82.PubMedGoogle Scholar
  8. 8.
    Jensen, H., Engedal, H., and Selmer Satersdal, T. (1976) Virchows Arch. B. Cell Path., 21, 1–12.Google Scholar
  9. 9.
    Quiani, F., Cigola, E., Lagrasta, C., Saccani, G., Quiani, E., Rossi, C., Olivetti, G., and Anversa, P. (1994) Circ. Res., 75, 1050–1063.PubMedGoogle Scholar
  10. 10.
    Tsyplenkova, V. G., and Beskrovnaya, N. N. (1993) Arkhiv Patol., 55, 26–29.Google Scholar
  11. 11.
    Takemura, G., Takatsu, Y., Sakaguchi, H., and Fujiwara, H. (1997) Pathol. Res. Pract., 193, 305–311.PubMedGoogle Scholar
  12. 12.
    Kino, M. (1981) J. Mol. Cell. Cardiol., 13, 5–21.PubMedGoogle Scholar
  13. 13.
    Skulachev, V. P. (2001) Trends Biochem. Sci., 26, 23–29.PubMedGoogle Scholar
  14. 14.
    De Vos, K., Severin, F., van Herreweghe, F., Goossens, V., Hyman, A., and Grooten, J. (2000) J. Cell Biol., 149, 1207–1214.PubMedGoogle Scholar
  15. 15.
    Marchenko, N. D., Zaika, A., and Moll, U. M. (2000) J. Biol. Chem., 275, 16202–16212.PubMedGoogle Scholar
  16. 16.
    Li, H., Kolluri, S. K., Gu, J., Dawson, M. I., Cao, X., Hobbs, P. D., Lin, B., Chen, G. Q., Lu, J. S., Lin, F., Xie, Z., Fontana, J. A., Reed, J. C., and Zhang, X. K. (2000) Science, 289, 1159–1164.PubMedGoogle Scholar
  17. 17.
    Joza, N., Susin, S. A., Daugas, E., Stanford, W. L., Cho, S. K., Li, C. Y. J., Sasaki, T., Elia, A. J., Cheng, H. Y. M., Ravagnan, L., Ferri, K. F., Zamzami, N., Wakeham, A., Hakem, R., Yoshida, H., Kong, Y. Y., Mak, T. W., Zuniga-Pflucker, J. C., Kroemer, G., and Penninger, J. M. (2001) Nature, 410, 549–554.Google Scholar
  18. 18.
    Skulachev, V. P. (2001) Exp. Gerontol., 36, 995–1024.PubMedGoogle Scholar

Copyright information

© MAIK “Nauka/Interperiodica” 2001

Authors and Affiliations

  • L. E. Bakeeva
    • 1
  • V. P. Skulachev
    • 1
  • Yu. V. Sudarikova
    • 2
  • V. G. Tsyplenkova
    • 2
  1. 1.Department of Bioenergetics, Belozersky Institute of Physico-Chemical Biologyomonosov Moscow State University, MoscowRussia
  2. 2.Russian Cardiology ComplexMinistry of Health and Medical IndustryMoscowRussia

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