Journal of Autism and Developmental Disorders

, Volume 31, Issue 6, pp 551–555 | Cite as

Functional Genomics Approaches to a Primate Model of Autistic Symptomology

  • Scott E. Hemby
  • Mar M. Sanchez
  • James T. Winslow


Several studies indicate a primary dysfunction of the temporal lobe in autism, specifically the hippocampal formation and entorhinal cortex (EC). Assessment of gene expression in the EC and hippocampus will provide insight into the subtle alterations in neuronal function associated with autism. To this end, evaluations in a primate model of social attachment, which produces behaviors associated with autism, in addition to the use of human post-mortem tissue from individuals diagnosed with autism will provide heretofore unattainable information of how the complex neural circuitry of this region is altered in autism. Identification of altered expression of multiple genes should provide a molecular “fingerprint” of autism and may provide new targets for pharmacotherapeutic intervention.

Autism gene expression temporal lobe rhesus monkey functional genomics 


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Copyright information

© Plenum Publishing Corporation 2001

Authors and Affiliations

  • Scott E. Hemby
    • 1
    • 2
    • 3
  • Mar M. Sanchez
    • 2
    • 4
  • James T. Winslow
    • 2
    • 4
  1. 1.Department of PharmacologyEmory University School of MedicineAtlanta
  2. 2.Department of Psychiatry and Behavioral SciencesEmory University School of MedicineAtlanta
  3. 3.Division of NeuroscienceYerkes Regional Primate Research CenterAtlanta
  4. 4.Division of PsychobiologyYerkes Regional Primate Research CenterAtlanta

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