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Journal of Radioanalytical and Nuclear Chemistry

, Volume 249, Issue 2, pp 279–282 | Cite as

Feasibility study for the production of 32 P-labeled diphosphonic acids by neutron irradiation and radiochemical separation

  • B. WierczinskiEmail author
  • R. A. M. J. Claessens
  • J. J. M. de Goeij
  • Z. I. Kolar
  • K. J. Volkers
Article

Abstract

Two simple diphosphonates, CH6P2 O6(MDP) and C2 H8 P2 O7 (HEDP),have been irradiated with neutrons to produce the corresponding 32P-labeled compounds. After irradiation for 0.5–5 hours in a thermalneutron flux of 4.2 . 1016 n . m —2 s—1 the irradiated compounds were dissolved and fractionated using a SephadexG10 column. The separated fractions were identified using planar paper chromatographyand autoradiography. The labeling yield was ca 35% for each of the compounds,and the specific activity attainable ranged up to 4.8 GBq . mol —1 . For practical applications, the labeled diphosphonates have to bepurified further.

Keywords

Physical Chemistry Inorganic Chemistry Feasibility Study Neutron Irradiation Diphosphonates 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Kluwer Academic Publishers/Akadémiai Kiadó 2001

Authors and Affiliations

  • B. Wierczinski
    • 1
    Email author
  • R. A. M. J. Claessens
    • 1
  • J. J. M. de Goeij
    • 1
  • Z. I. Kolar
    • 1
  • K. J. Volkers
    • 1
  1. 1.Department of Radiochemistry, Interfaculty Reactor InstituteDelft University of TechnologyDelftThe Netherlands

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