Reliability and Accuracy in Determining Metabolite Concentrations in Brain Tissue by in Vivo NMR Spectrometry
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The paper examines the possible sources of error in the NMR determination of the concentration of N-acetylaspartate (NAA) in the brain white matter. Software has been written to minimize the systematic errors and determine the NAA concentration with an error of less than 3%. In two males of ages 19 and 60, the NAA concentrations in the white matter were respectively 11.0 ± 2.3% and 10.6 ± 1.0% mmol/liter, while the myoinositol concentrations were respectively 4.03 ± 4% and 9.03 ± 4.2% mmol/liter.
KeywordsPhysical Chemistry Analytical Chemistry White Matter Brain Tissue Systematic Error
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- 1.V. A. Ivanov, Author's Certificate 1112266 USSR (priority from 1960Google Scholar