Measurement Techniques

, Volume 44, Issue 9, pp 959–964 | Cite as

Reliability and Accuracy in Determining Metabolite Concentrations in Brain Tissue by in Vivo NMR Spectrometry

  • Yu. I. Neronov


The paper examines the possible sources of error in the NMR determination of the concentration of N-acetylaspartate (NAA) in the brain white matter. Software has been written to minimize the systematic errors and determine the NAA concentration with an error of less than 3%. In two males of ages 19 and 60, the NAA concentrations in the white matter were respectively 11.0 ± 2.3% and 10.6 ± 1.0% mmol/liter, while the myoinositol concentrations were respectively 4.03 ± 4% and 9.03 ± 4.2% mmol/liter.


Physical Chemistry Analytical Chemistry White Matter Brain Tissue Systematic Error 
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  1. 1.
    V. A. Ivanov, Author's Certificate 1112266 USSR (priority from 1960Google Scholar

Copyright information

© Plenum Publishing Corporation 2001

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  • Yu. I. Neronov

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