Journal of Radioanalytical and Nuclear Chemistry

, Volume 249, Issue 2, pp 421–427 | Cite as

Selenium status and cancer mortality in subjects residing in four Canadian provinces

  • J. S. MorrisEmail author
  • T. Rohan
  • C. L. Soskolne
  • M. Jain
  • T. L. Horsman
  • V. L. Spate
  • C. K. Baskett
  • M. M. Mason
  • T.A. Nichols


The objective of this study was to measure selenium status in maleand female Canadian subjects relative to cancer mortality in their respectiveprovinces. Toenail specimens from 755 subjects, 377 males and 378 females,living in Vancouver (186), Edmonton (188), Toronto (197) and Montreal (184)were analyzed by instrumental neutron activation analysis giving means of0.968±0.177, 0.950±0.148, 0.932±0.135 and 0.896±0.127ppm Se, respectively. The effect of selenium determinants such as gender,selenium supplementation and smoking on selenium status is presented. Detailsof the observed inverse relationship of selenium status and cancer mortalityare discussed.


Physical Chemistry Inorganic Chemistry Selenium Inverse Relationship Activation Analysis 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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  1. 1.
    T. C. Stadman, Ann. Rev. Biochem., 65 (1996) 83.CrossRefGoogle Scholar
  2. 2.
    D. H. Holben,A. M. Smith, J. Am. Diet. Assoc., 99 (1999) 836.CrossRefGoogle Scholar
  3. 3.
    H. Ganther, Carcinogenesis, 20 (1999) 1657.CrossRefGoogle Scholar
  4. 4.
    L. C. Clark,G. F. Combs,B. W. Turnbull,E. H. Slate,D. K. Chalker,J. Chow,L. S. Davis,R. A. Grover,G. F. Graham,E. G. Gross,A. Krongrad,J. L. LESHER Jr.,H. K. Park,B. B. Sanders Jr.,C. Smith,J. R. Taylor, JAMA 276 (1996) 1957.CrossRefGoogle Scholar
  5. 5.
    K. Yoshizawa,W. C. Willett,J. S. Morris,M. J. Stampfer,D. Spiegelman,E. B. Rimm,E. Giovannucci, JNCI, 90 (1998) 1219.CrossRefGoogle Scholar
  6. 6.
    E. Giovannucci,E. B. Rimm,G. A. Colditz,M. J. Stampfer,A. Ascherio,C. C. Chute et al., J. Natl. Cancer Inst., 85 (1993) 1571.CrossRefGoogle Scholar
  7. 7.
    E. Giovannucci,A. Ascherio,E. B. Rimm,M. J. Stampfer,G. A. Colditz,W. C. Willett, J. Natl. Cancer Inst., 87 (1995) 1767.CrossRefGoogle Scholar
  8. 8.
    R. J. Shamberger,S. A. Tytko,C. E. Willis, Arch. Environ. Health, 31 (1976) 1231.CrossRefGoogle Scholar
  9. 9.
    J. S. Morris,M. J. Stampfer,W. C. Willett, Biol. Trace Elem. Res., 5 (1983) 529.CrossRefGoogle Scholar
  10. 10.
    M. P. Longnecker,D. O. Stram,P. R. Taylor,O. A. Levander,M. Howe,C. Veillon,J. S. Morris et al., Epidemiology, 7 (1996) 384.CrossRefGoogle Scholar
  11. 11.
    M. M. MASON,J. S. Morris,V. L. Spate,C. K. Baskett,T. A. Nichols,T. L. Horsman,L. Le Marchand,L. N. Kolonel, Radioanal. Nucl. Chem., 236 (1998) 29.CrossRefGoogle Scholar
  12. 12.
    M. Garland,J. S. Morris,B. A. Rosner,M. J. Stampfer,V. L. Spate,Baskett et al., Cancer Epidemiol. Biomarkers Prev., 2 (1993) 493.PubMedGoogle Scholar
  13. 13.
    C. K. Baskett,V. L. Spate,J. S. Morris,H. D. Anderson,M. M. Mason,C. L. Reams,T. P. Cheng,K. R. Zinn,G. M. Hill,R. P. Dowdy, J. Radioanal. Nucl. Chem., 195 (1995) 97.CrossRefGoogle Scholar
  14. 14.
    D. L. Hunter,J. S. Morris,C. G. Chute,E. Kushner,G. A. Colditz,M. J. Stampfer et al., Am. J. Epidemiol., 132 (1990) 114.CrossRefGoogle Scholar
  15. 15.
    W. C. Willett,B. F. Polk,J. S. Morris,M. J. Stampfer,S. Pressel,B. Rosner et al., Lancet, 2 (1983) 130.CrossRefGoogle Scholar
  16. 16.
    M. H. Criqui,S. Bangdiwala,M. D. Goodman,W. S. Blaner,J. S. Morris,S. Kritchevsky,K. Lippel,I. Mebane,H. A. Tyroler, Ann. Epidemiol., 1 (1991) 385.CrossRefGoogle Scholar
  17. 17.
    K. J. Helzlsouer,G. W. Comstock,J. S. Morris, Cancer Res., 49 (1989) 6144.PubMedGoogle Scholar
  18. 18.
    P. G. J. Burney,G. W. Comstock,J. S. Morris, Am. J. Clin. Nutr., 49 (1989) 895.CrossRefGoogle Scholar
  19. 19.
    G. W. Comstock,A. J. Alberg,H. Y. Huang,K. Wu,A. E. Burke,S. C. Hoffman,E. P. Norkus,M. Gross,R. G. Cutler,J. S. Morris,V. L. Spate,K. Helzlsouer, Cancer Epidemiol. Biomarkers Prev., 6 (1997) 907.PubMedGoogle Scholar
  20. 20.
    R. J. Coates,N. S. Weiss,J. R. Daling,J. S. Morris,R. F. LABBE, Am. J. Epidemiol., 128 (1988) 515.CrossRefGoogle Scholar
  21. 21.
    S. E. Schober,G. W. Comstock,K. J. Helzlsouer,R. M. Salkeld,J. S. Morris,A. A. Rider,R. Brookmeyer, Am. J. Epidemiol., 126 (1987) 1033.CrossRefGoogle Scholar
  22. 22.
    A. Nomura,L. K. Heilbrun,J. S. Morris,G. N. Stemmermann, J. Natl. Cancer Inst., 79 (1987) 103.PubMedGoogle Scholar
  23. 23.
    K. E. Brock,G. Gridley,J. S. Morris,W. C. Willett, J. Natl. Cancer Inst., 83 (1991) 292.CrossRefGoogle Scholar
  24. 24.
    W. Zheng,W. J. Blot,E. L. Diamond,E. P. Norkus,V. Spate,J. S. Morris,G. W. Comstock, Cancer Res., 53 (1993) 795.PubMedGoogle Scholar
  25. 25.
    A. M. Batieha,H. K. Armenian,E. P. Norkus,J. S. Morris,V. L. Spate,G. W. Comstock, Cancer Epidemiol. Biomarkers Prev., 2 (1993) 335.PubMedGoogle Scholar
  26. 28.
    P. L. Horn-Ross,A. S. Whittemore,D. W. West,I. R. McDougall,J. S. Morris,V. L. Spate, in: Proc. 6th Intern. Thyroid Symp., Blackwell Wissenschaft, Vienna, 1996, p. 185.Google Scholar
  27. 26.
    R. A. Breslow,A. J. Alberg,K. J. Helzlsouer,T. L. Bush,E. P. Norkus,J. S. Morris,V. Spate,G. W. Comstock, Cancer Epidemiol. Biomarkers Prev., 4 (1995) 837.PubMedGoogle Scholar
  28. 29.
    M. R. Karagas,E. R. Greenberg,D. Nierenberg,T. A. Stukel,J. S. Morris,M. M. Stevens,J. A. Baron, Cancer Epidemiol. Biomarkers Prev., 6 (1997) 25. 27. K. J. Helzlsouer, A. J. Alberg, E. P. Norkus, J. S. MORRIS, S. C. HOFFMAN, G. W. Comstock, J. Natl. Cancer Inst., 88 (1996) 32.PubMedGoogle Scholar
  29. 30.
    D. J. Hunter,J. S. Morris,M. J. Stampfer,G. A. Colditz,F. E. Speizer,W. C. Willett, JAMA 264 (1990) 1128.CrossRefGoogle Scholar

Copyright information

© Kluwer Academic Publishers/Akadémiai Kiadó 2001

Authors and Affiliations

  • J. S. Morris
    • 1
    Email author
  • T. Rohan
    • 2
  • C. L. Soskolne
    • 3
  • M. Jain
    • 4
  • T. L. Horsman
    • 1
  • V. L. Spate
    • 1
  • C. K. Baskett
    • 1
  • M. M. Mason
    • 1
  • T.A. Nichols
    • 1
  1. 1.Research Reactor CenterUniversity of Missouri-ColumbiaColumbiaUSA
  2. 2.Department of Epidemiology and Social MedicineAlbert Einstein College of MedicineBronx, NYUSA
  3. 3.Department of Public Health SciencesUniversity of AlbertaEdmontonCanada
  4. 4.Department of Public Health SciencesUniversity of TorontoTorontoCanada

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