A longitudinal study of health related quality of life and utility measures in patients with advanced breast cancer
- 120 Downloads
Health related quality of life (HRQOL) measures are now accepted as indicators of efficacy in the palliative treatment of cancer. Utility measures may also provide valuable information yet they have been applied less frequently. To assess the application of a time trade-off (TTO) utility measure and its concordance with the Spitzer uniscale and quality of life index (QLI) 38 women with advanced, symptomatic breast cancer were studied over a 12 month period. The correlation coefficient for QLI and TTO values was 0.54 and for uniscale and TTO 0.62. Using generalized estimating equations the regression of TTO scores on QLI and uniscale scores was significant at baseline. In longitudinal analyses results were significant only for QLI. Although all participants completed the HRQOL measures only 24 (63%) were prepared to trade time. The remaining 14 (32%) stated they felt too well to trade. Those prepared to trade time recorded significantly worse mean HRQOL scores throughout the study compared to those who felt too well to trade and had tumors which showed a poorer response to therapy. In this preliminary study utility and HRQOL scores were generally favorable throughout the 12 month study period and showed fair to moderate concordance. Further research in larger patient groups is required to better define the relationships between utility and HRQOL measures.
Unable to display preview. Download preview PDF.
- 10.Lalonde L, Clarke AE, Grover SA. Comparing a health status instrument with conventional utility instruments. (Abstract) Qual Life Res 1995; 4: 451.Google Scholar
- 11.Tsevat J, Solzan JG, Tolan KK, et al. Health status and utilities of HIV+ and primary care patients. (Abstract) Clin Res 1992; 40: 569A.Google Scholar
- 12.Sherbourne C, Sturm R, Wells KB. Development of utility scores for the SF-12. (Abstract) Qual Life Res 1997; 6: 721.Google Scholar
- 15.Bland JM, Altman DG. Calculating correlation coefficients with repeated observations: Part 2 — correlation between subjects. Br Med J 1995; 310: 633.Google Scholar
- 23.Weeks J, O'Leary J, Fairclough D, et al. The ‘Q-TILITY INDEX': A new tool for assessing health related quality of life and utilities in clinical trials and clinical practice. (Abstract) Proc ASCO 1994; 13: 436.Google Scholar
- 25.Drummond MF, Stoddard GL, Torrance GW. Methods for the Economic Evaluation of Health Care Programmes. New York: Oxford University Press, 1987.Google Scholar