Bulletin of Experimental Biology and Medicine

, Volume 132, Issue 3, pp 832–836 | Cite as

Effect of Chronic Inhalation of Toluene and Dioxane on Activity of Free Radical Processes in Rat Ovaries and Brain

  • S. O. Burmistrov
  • A. V. Arutyunyan
  • M. G. Stepanov
  • T. I. Oparina
  • V. M. Prokopenko


The effects of toluene and dioxane inhalations on the intensity of free radical oxidation in rat ovaries and brain cortex were studied. Both toxins in a dose 10-fold surpassimg the maximum permissible concentration increased activity of glutathione peroxidase in brain tissue; moreover, toluene increased chemiluminescence intensity, which attested to activation of free radical processes. In ovarian tissue toluene increased activities of glutathione peroxidase and catalase and the intensity of lipid peroxidation. These changes were associated with the appearance of normally absent circadian rhythm.

toluene dioxane free radicals ovaries brain circadian rhythms 


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  1. 1.
    E. K. Ailamazyan, T. V. Belyaeva, E. G. Vinogradova, et al., Vestn. Ross. Assotsiatsii Akush. Ginekol., No. 3, 72-78 (1997).Google Scholar
  2. 2.
    A. V. Arutyunyan, M. G. Stepanov, A. V. Korenevskii, et al., Vestn. Ross. Assotsiatsii Akush. Ginekol., No. 4, 28-31.Google Scholar
  3. 3.
    E. B. Arushunyan and L. G. Arushunyan, Eksp. Klin. Farmakol., 60, No. 6, 71-77 (1997).Google Scholar
  4. 4.
    S. O. Burmistrov, O. N. Mashek, and I. I. Stepanov, Farmakol. Toksikol., No. 5, 56-58 (1992).Google Scholar
  5. 5.
    I. I. Kulinskii and L. S. Kolesnichenko, Uspekhi Sovrem. Biol., 113, No. 1, 107-122 (1993).Google Scholar
  6. 6.
    V. I. Moin, Lab. Delo, No. 12, 724-727 (1986).Google Scholar
  7. 7.
    L. M. Seledtsov, Vopr. Med. Khim., 41, No. 3, 50-53 (1995).Google Scholar
  8. 8.
    L. S. Tselkovich and V. S. Rogacheva, Akush. Ginek., No. 2, 24-27 (1998).Google Scholar
  9. 9.
    A. Agostini, G. C. Cerli, L. Beretta, and M. Bianchi, J. Clin. Chem. Clin. Biochem., 17, 771-773 (1980).Google Scholar
  10. 10.
    A. Boveris, E. Cadenas, R. Reiter, et al., Proc. Natl. Acad. Sci. USA, 77, 347-351 (1979).Google Scholar
  11. 11.
    S. T. Inouye and S. Shibata, Neurosci. Res., 20, No. 3, 109-130 (1994).PubMedGoogle Scholar
  12. 12.
    R. L. Levine, D. Garland, C. N. Oliver, et al., Methods Enzymol., 186, 464-478 (1990).PubMedGoogle Scholar
  13. 13.
    C. M. Martines, Biochimie, 77, No. 3, 147-161 (1995).PubMedGoogle Scholar

Copyright information

© Plenum Publishing Corporation 2001

Authors and Affiliations

  • S. O. Burmistrov
    • 1
  • A. V. Arutyunyan
    • 1
  • M. G. Stepanov
    • 1
  • T. I. Oparina
    • 1
  • V. M. Prokopenko
    • 1
  1. 1.Laboratory of Perinatal Biochemistry, D. O. Ott Institute of Obstetrics and GynecologyRussian Academy of Medical SciencesSt. Petersburg

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