Journal of Materials Science: Materials in Medicine

, Volume 12, Issue 10, pp 871–877

Biomimetic coatings functionalized with adhesion peptides for dental implants

  • S. Roessler
  • R. Born
  • D. Scharnweber
  • H. Worch
  • A. Sewing
  • M. Dard
Article

DOI: 10.1023/A:1012807621414

Cite this article as:
Roessler, S., Born, R., Scharnweber, D. et al. Journal of Materials Science: Materials in Medicine (2001) 12: 871. doi:10.1023/A:1012807621414

Abstract

A complete biological integration into the surrounding tissues (bone, gingiva) is a critical step for clinical success of a dental implant. In this work biomimetic coatings consisting either of collagen type I (for the gingiva region) and hydroxyapatite (HAP) or mineralized collagen (for the bone interface) have been developed as suitable surfaces regarding the interfaces. Additionally, using these biomimetic coatings as a matrix, adhesion peptides were bound to further increase the specificity of titanium implant surfaces. To enhance cell attachment in the gingiva region, a linear adhesion peptide developed from a laminin sequence (TWYKIAFQRNRK) was bound to collagen, whereas for the bone interface, a cyclic RGD peptide was bound to HAP and mineralized collagen using adequate anchor systems. The biological potential of these coatings deduced from cell attachment experiments with HaCaT human keratinocytes and MC3T3-E1 mouse osteoblasts showed the best results for collagen and laminin sequence coating for the gingiva region and mineralized collagen and RGD peptide coatings for regions with bone contact. Our concept opens promising approaches to improve the biological integration of dental implants.

© 2001 Kluwer Academic Publishers

Copyright information

© Kluwer Academic Publishers 2001

Authors and Affiliations

  • S. Roessler
    • 1
  • R. Born
    • 1
  • D. Scharnweber
    • 1
  • H. Worch
    • 1
  • A. Sewing
    • 2
  • M. Dard
    • 2
  1. 1.Institut für WerkstoffwissenschaftTechnische Universität DresdenDresdenGermany
  2. 2.Merck Biomaterial GmbHDarmstadtGermany

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