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The Chlorhexidine: beta;-Cyclodextrin Inclusion Compound: Preparation, Characterization and Microbiological Evaluation

  • Maria Esperanza Cortés
  • Rubén Dario Sinisterra
  • Mario Julio Avila-Campos
  • Nicolau Tortamano
  • Rodney Garcia Rocha
Article

Abstract

The 1 : 2 chlorhexidine : β-cyclodextrin(Cx : βCD) complex was prepared and characterised using X-ray crystallography, infrared spectroscopy, thermal analysis and nuclearmagnetic resonance. The minimum inhibitory concentration (MIC50) of the chlorhexidine : β-cyclodextrin inclusion compoundagainst Streptococcus mutans, Eubacterium Lentum, Fusobacterium nucleatum, Bacteroides fragilis andActinomices actinomycetemcomitans was determined. TheCx : βCD inclusion compound inhibited the bacterial growth at a low concentration.

chlorhexidine β-cyclodextrin minimum inhibitory concentration 

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Copyright information

© Kluwer Academic Publishers 2001

Authors and Affiliations

  • Maria Esperanza Cortés
    • 1
  • Rubén Dario Sinisterra
    • 2
  • Mario Julio Avila-Campos
    • 3
  • Nicolau Tortamano
    • 4
  • Rodney Garcia Rocha
    • 4
  1. 1.Dpto. de Odontologia Restauradora, Faculdade de OdontologiaUniversidade Federal de Minas GeraisBelo HorizonteBrazil
  2. 2.Dpto. de Química, ICEX, UFMGBrazil
  3. 3.Dpto. de Microbiologia, ICBBrazil
  4. 4.Faculdade de OdontologiaUniversidade de São PauloBrazil

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