Biomedical Microdevices

, Volume 3, Issue 4, pp 323–330

A Microfabricated Rotary Pump

  • Hou-Pu Chou
  • Marc A. Unger
  • Stephen R. Quake
Article

DOI: 10.1023/A:1012412916446

Cite this article as:
Chou, HP., Unger, M.A. & Quake, S.R. Biomedical Microdevices (2001) 3: 323. doi:10.1023/A:1012412916446

Abstract

Because microfluidic devices operate at low Reynolds number, many fluidic operations are limited by diffusion. We have developed a microfabricated rotary pump and demonstrated that active mixing can be used to overcome the slow diffusion process in two applications. First, we showed that mixing of reagents could be efficiently accomplished for objects of a wide range of diffusion constants. Second, we showed how reaction kinetics of a surface-binding assay can be enhanced by nearly two orders of magnitude.

microfluidics microelectromechanical systems soft lithography lab on a chip diffusion 

Copyright information

© Kluwer Academic Publishers 2001

Authors and Affiliations

  • Hou-Pu Chou
    • 1
  • Marc A. Unger
    • 2
  • Stephen R. Quake
    • 2
  1. 1.Deptartment of Electrical EngineeringCalifornia Institute of TechnologyPasadena
  2. 2.Deptartment of Applied PhysicsCalifornia Institute of TechnologyPasadena

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