Molecular Biology

, Volume 35, Issue 5, pp 647–659 | Cite as

Structural Aspects of Interaction of Homeodomains with DNA

  • R. K. Ledneva
  • A. V. Alexeevskii
  • S. A. Vasil'ev
  • S. A. Spirin
  • A. S. Karyagina
Article

Abstract

This review is devoted to the structural aspects of interaction of homeodomains with DNA. Presented are the list of all homeodomains with known spatial structure and the alignment of their amino acid sequences. The structure of homeodomains and contacts of their amino acid residues with DNA bases and sugar-phosphate backbone are described. The role of water molecules in DNA binding is discussed. Structures of multicomponent protein complexes on DNA including homeodomains are characterized.

homeodomain DNA–protein complex spatial structure 

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Copyright information

© MAIK “Nauka/Interperiodica” 2001

Authors and Affiliations

  • R. K. Ledneva
    • 1
  • A. V. Alexeevskii
    • 1
  • S. A. Vasil'ev
    • 2
  • S. A. Spirin
    • 1
  • A. S. Karyagina
    • 2
  1. 1.Belozersky Institute of Physico-Chemical BiologyMoscow State UniversityMoscowRussia
  2. 2.National Institute of Agricultural Biotechnology, Russian Academy of Agricultural SciencesMoscowRussia

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