Advertisement

Pharmaceutical Research

, Volume 15, Issue 11, pp 1792–1795 | Cite as

Linear Correlation of the Fraction of Oral Dose Absorbed of 64 Drugs Between Humans and Rats

  • Win L. Chiou
  • Abhijit Barve
Article
oral absorption rats humans inter-species 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

REFERENCES

  1. 1.
    G. L. Amidon, H. Lennernäs, V. P. Shah, and J. R. Crison. A theoretical basis for a biopharmaceutical drug classification: The correlation of in vitro drug product dissolution and in vivo bioavailability. Pharm. Res. 12:413–420 (1995).Google Scholar
  2. 2.
    U. Fagerholm, M. Johansson, and H. Lennernäs. Comparison between permeability coefficients in rat and human jejunum. Pharm. Res. 13:1336–1342 (1996).Google Scholar
  3. 3.
    W. L. Chiou. Determination of drug permeability in a flat or distended stirred intestine: Prediction of fraction dose absorbed in humans after oral administration. Int. J. Clin. Pharmacol. Ther. 32:474–482 (1994).Google Scholar
  4. 4.
    W. L. Chiou. The validation of the intestinal permeability approach to predict oral fraction of dose absorbed in humans and rats. Biopharm. Drug. Disp. 16:71–75 (1995).Google Scholar
  5. 5.
    M. E. Dowty and C. R. Dietsch. Improved prediction of in vivo peroral absorption from in vitro intestinal permeability using an internal standard to control for intra-and inter-rat variability. Pharm. Res. 14:1792–1797 (1997).Google Scholar
  6. 6.
    N. Takamatsu, L. S. Welage, N. M. Idkaidek, D. Liu, P. I-Der Lee, Y. Hayashi, J. K. Rhie, H. Lennernäs, J. L. Barnett, V. P. Shah, L. Lesko, and G. L. Amidon. Human intestinal permeability of piroxicam, propranolol, phenylalanine, and PEG 400 determined by jejunal perfusion. Pharm. Res. 14:1127–1132 (1997).Google Scholar
  7. 7.
    P. Artursson and J. Karlsson. Correlation between oral drug absorption in humans and apparent drug permeability coefficients in human intestinal epithelial (Caco-2) cells. Biochem. Biophys. Res. Commun. 175:880–885 (1991).Google Scholar
  8. 8.
    P. Artursson, K. Palm, and K. Luthman. Caco-2 monolayers in experimental and theoretical predictions of drug transport. Advanced Drug Delivery Reviews 22:67–84 (1996).Google Scholar
  9. 9.
    P. Artursson and R. Borchardt. Intestinal drug absorption and metabolism in cell cultures: Caco-2 and beyond. Pharm. Res. 14:1655–1658 (1997).Google Scholar
  10. 10.
    W. L. Chiou. The author replies to Lennernäs et al. J. Pharmacokin. Biopharm. 23:323–331 (1995).Google Scholar
  11. 11.
    W. L. Chiou. New perspectives on the theory of permeability and resistance in the study of drug transport and absorption. J. Pharmacokin. Biopharm. 24:433–442 (1996).Google Scholar
  12. 12.
    M. G. Lee and W. L. Chiou. Studies on potential factors affecting incomplete absorption of furosemide: Gastric first-pass effect. J. Pharmacokin. Biopharm. 11:623–640 (1983).Google Scholar
  13. 13.
    F. H. Hsu, T. Prueksaritanont, M. G. Lee, and W. L. Chiou. The phenomenon and cause of dose-dependent oral absorption of chlorothiazide in rats: Extrapolation to human data based on the body surface area concept. J. Pharmacokin. Biopharm. 15:369–383 (1987).Google Scholar
  14. 14.
    L. Z. Benet, S. Øie, and J. B. Schwartz. Design and Optimization of dosage regimens; Pharmacokinetic data. In A. Goodman Gilman, J. G. Hardman, L. E. Limbard, P. B. Molinoff, and R. W. Ruddon (eds.) Goodman and Gilman's The Pharmacological Basis of Therapeutics, 9th edition, pp. 1707–1792, McGraw Hill, NY, 1996.Google Scholar
  15. 15.
    S. Chong, S. A. Dando, K. M. Soucek, and R. A. Morrison. In vitro permeability through Caco-2 cells is not quantitatively predictive of in vivo absorption for peptide-like drugs absorbed via the dipeptide transporter system. Pharm. Res. 13:120–123 (1996).Google Scholar
  16. 16.
    A. Strocchi, G. Corazza, J. Furne, C. Fine, A. DiSario, G. Gasbarrini, and M. D. Levitt. Measurements of the jejunal unstirred layer in normal subjects and patients with celiac disease. Am. J. Physiol. 270:G487–G491 (1996).Google Scholar
  17. 17.
    Y. L. He, S. Murby, G. Warhurst, L. Gifford, D. Walker, J. Ayrton, R. Eastmond, and M. Rowland. Species differences in size discrimination in the paracellular pathway reflected by oral bioavailability of poly(ethylene glycol) and D-peptides. J. Pharm. Sci. 87:626–633 (1998).Google Scholar
  18. 18.
    D. C. Taylor, R. Grundy, and B. Loveday. Chronic dog intestinal loop model for studying drug absorption as exemplified by beta-adrenoceptor blocking agents, atenolol and propranolol. J. Pharm. Sci. 70:516–21 (1981).Google Scholar

Copyright information

© Plenum Publishing Corporation 1998

Authors and Affiliations

  • Win L. Chiou
    • 1
  • Abhijit Barve
    • 1
  1. 1.Department of Pharmaceutics and PharmacodynamicsUniversity of Illinois at ChicagoChicago

Personalised recommendations