Pharmaceutical Research

, Volume 15, Issue 10, pp 1637–1639 | Cite as

Dodecylmaltoside-Mediated Nasal and Ocular Absorption of Lyspro-Insulin: Independence of Surfactant Action from Multimer Dissociation

  • Dennis J. Pillion
  • Susan Hosmer
  • Elias Meezan
Article
drug delivery diabetes mellitus excipient insulin eye nose 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

REFERENCES

  1. 1.
    S. Hirai, T. Ikenaga, and T. Matsuzawa. Nasal absorption of insulin in dogs, Diabetes. 27:296-299 (1978).PubMedGoogle Scholar
  2. 2.
    G. C. Y. Chiou, C. Chuang, and M. S. Chang. Reduction of blood glucose concentration with insulin eyedrops, Diabetes Care. 11:750-751 (1988).PubMedGoogle Scholar
  3. 3.
    D. J. Pillion, J. D. Bartlett, E. Meezan, M. Yang, R. J. Crain, and W. E. Grizzle. Systemic absorption of insulin delivered topically to the rat eye, Invest. Ophthalmol. Vis. Sci. 32:3021-3027 (1991).PubMedGoogle Scholar
  4. 4.
    D. J. Pillion, J. A. Atchison, J. Stott, D. L. McCracken, C. Garguilo, and E. Meezan. Efficacy of insulin eyedrops, J. Ocul. Pharmacol. 10:461-470 (1994).PubMedGoogle Scholar
  5. 5.
    A. C. Moses, G. S. Gordon, M. C. Carey, and J. S. Flier. Insulin administered intranasally as an insulin-bile salt aerosol. Effectiveness and reproducibility in normal and diabetic subjects, Diabetes. 32:1040-1047 (1983).PubMedGoogle Scholar
  6. 6.
    J. Hilsted, S. Madsbad, A. Hvidberg, et al. Intranasal insulin therapy: the clinical realities, Diabetologia. 38:680-684 (1995).PubMedGoogle Scholar
  7. 7.
    K. Dreyer, A. Vaag, K. Bech, P. Hansen, A. R. Sorensen, and N. Mygind. Intranasal administration of insulin with phospholipid as absorption enhancer: Pharmacokinetics in normal subjects, Diab. Med. 9:335-340 (1992).Google Scholar
  8. 8.
    B. J. Aungst, A. J. Rogers, and E. Shefter. Comparison of nasal, rectal, sublingual and intramuscular insulin efficacy and the effects of a bile salt absorption promotor, J. Pharmacol. Exp. Therap. 244:23-27 (1988).Google Scholar
  9. 9.
    D. J. Pillion, J. A. Atchison, C. Garguilo, J. Stott, P. Wang, and E. Meezan. Insulin delivery in nosedrops: New formulations containing alkylglycosides, Endocrinology. 135:1386-1391 (1994).Google Scholar
  10. 10.
    D. J. Pillion, P. Wang, J. Yorks, P. McCann, and E. Meezan. Systemic absorption of insulin and glucagon applied to the eyes of rats and a diabetic dog, J. Ocul. Pharmacol. Tox. 11:283-295 (1995).Google Scholar
  11. 11.
    D. J. Pillion, J. A. Atchison, and E. Meezan. Alkylglycosides enhance systemic absorption of insulin applied topically to the rat eye, J. Pharmacol. Exp. Therap. 271:1274-1280 (1994).Google Scholar
  12. 12.
    D. J. Pillion, D. L. McCracken, M. Yang, and J. A. Atchison. Glucagon administration to the rat via eyedrops, J. Ocul. Pharmacol. 8:349-358 (1992).PubMedGoogle Scholar
  13. 13.
    D. C. Howey, R. R. Bowsher, R. L. Brunelle, and J. R. Woodworth. [Lys(B28),Pro(B29)]-human insulin: a rapidly absorbed analog of human insulin, Diabetes. 43:396-402 (1994).PubMedGoogle Scholar

Copyright information

© Plenum Publishing Corporation 1998

Authors and Affiliations

  • Dennis J. Pillion
    • 1
  • Susan Hosmer
    • 1
  • Elias Meezan
    • 1
  1. 1.Department of Pharmacology and ToxicologyUniversity of Alabama at BirminghamBirmingham

Personalised recommendations