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Antagonistic Interaction Between the Convulsant Activities of Pefloxacin and Its Main Metabolite Norfloxacin in Rats

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REFERENCES

  1. M. Danhof and G. Levy. Kinetics of drug action in disease states. I. Effect of infusion rate on phenobarbital concentrations in serum, brain and cerebrospinal fluid of normal rats at onset of loss of righting reflex. J. Pharmacol. Exp. Ther. 229:44-50 (1984).

    Google Scholar 

  2. A. Delon, F. Huguet, P. Courtois, J. M. Vierfond, S. Bouquet, and W. Couet. Pharmacokinetic-Pharmacodynamic contributions to the convulsant activity of pefloxacin and norfloxacin in rats. J. Pharmacol. Exp. Ther. 280:983-987 (1997).

    Google Scholar 

  3. W. Christ. Central nervous system toxicity of quinolones: human and animal findings. J. Antimicrob. Chemother. 26(Suppl.B):219-225 (1990).

    Google Scholar 

  4. A. Delon, C. Pariat, P. Courtois, S. Bouquet, and W. Couet. A new approach for early assessment of the epileptogenic potential of quinolones. Antimicrob. Agents Chemother. 42:2756-2758 (1998).

    Google Scholar 

  5. A. Delon, S. Bouquet, F. Huguet, V. Brunet, P. Courtois, and W. Couet. Pharmacokinetic-Pharmacodynamic contributions to the convulsant activity of fluoroquinolones in rats. Antimicrob. Agents Chemother. 43:1511-1515 (1999).

    Google Scholar 

  6. P. M. Klockowski and G. Levy. Kinetics of drug action in disease states. XXIV. Pharmacodynamics of diazepam and its active metabolites in rats. J. Pharmacol. Exp. Ther. 244:912-918 (1987).

    Google Scholar 

  7. L. M. Levasseur, A. Delon, W. R. Greco, P. Faury, S. Bouquet, and W. Couet. Development of a new quantitative approach for the isobolographic assessment of the convulsant interaction between pefloxacin and theophylline in rats. Pharm. Res. 15:1069-1076 (1998).

    Google Scholar 

  8. G. Montay, Y. Goueffon, and F. Roquet. Absorption, distribution, metabolic fate, and elimination of pefloxacin mesylate in mice, rats, dogs, monkey and humans. Antimicrob. Agents Chemother. 25:463-472 (1984).

    Google Scholar 

  9. U. Jaehde, M. W. E. Langemeijer, A. G. de Boer and D. D. Breimer. Cerebrospinal fluid transport and disposition of the quinolones ciprofloxacin and pefloxacin in rats. J. Pharmacol. Exp. Ther. 263:1140-1146 (1992).

    Google Scholar 

  10. W. R. Greco, G. Bravo, and J. C. Parsons. The search for synergy: a critical review from a response surface perspective. Pharmacol. Rev. 47:331-385 (1995).

    Google Scholar 

  11. W. R. Greco, H. S. Park, and Y. M. Rustum. Application of a new approach for the quantitation of drug synergism to the combination of cis-diamminedichloroplatinum and 1-beta-D-arabinofuranosylcytosine. Cancer Res. 50(17):5318-27 (1990).

    Google Scholar 

  12. S. Loewe and H. Muischnek. Effect of combinations: mathematical basis of problem. Arch. Exp. Pathol. Pharmakol. 114:313-326 (1926).

    Google Scholar 

  13. M. C. Berenbaum. The expected effect of a combination of agents: the general solution. J. Theor. Biol. 114:413-431 (1985).

    Google Scholar 

  14. J. Zhi and G. Levy. Isobolographic assessment of the convulsant interaction between theophylline and caffeine or pentylenetetrazol in rats. J. Pharm. Sci. 79:678-681 (1990).

    Google Scholar 

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Correspondence to William Couet.

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Delon, A., Levasseur, L.M., Giraudon, M. et al. Antagonistic Interaction Between the Convulsant Activities of Pefloxacin and Its Main Metabolite Norfloxacin in Rats. Pharm Res 16, 1894–1897 (1999). https://doi.org/10.1023/A:1011967813140

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  • DOI: https://doi.org/10.1023/A:1011967813140

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