Journal of Thrombosis and Thrombolysis

, Volume 11, Issue 3, pp 183–193

Plasminogen Activator Inhibitor Type-1 (Part One): Basic Mechanisms, Regulation, and Role for Thromboembolic Disease

  • Kurt Huber


Plasminogen activator inhibitor type-1 (PAI-1) is a rapid inhibitor of tissue plasminogen activator (tPA) in circulation. Evidence suggests that the PAI-1 concentration is responsible for the regulation of the endogenous fibrinolytic system through its tPA/PAI-1 interactions. Accordingly, increased levels of PAI-1 have emerged as a masker for an increased thrombolic risk. This article represents a status report of mechansism of action, regulation of plasma levels, as well as the role of PAI-1 in arterial and venous thromboembolic disease.

PAI-1 regulation thromboembolic disease 


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Copyright information

© Kluwer Academic Publishers 2001

Authors and Affiliations

  • Kurt Huber
    • 1
  1. 1.Department of CardiologyUniversity of Vienna, General HospitalViennaAustria

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