Advertisement

Pharmaceutical Research

, Volume 15, Issue 12, pp 1907–1910 | Cite as

Effect of ZTTA, a Prolyl Endopeptidase Inhibitor, on Memory Impairment in a Passive Avoidance Test of Rats with Basal Forebrain Lesions

  • Yoshiyuki Shishido
  • Masayoshi Furushiro
  • Shuichi Tanabe
  • Akira Taniguchi
  • Shusuke Hashimoto
  • Teruo Yokokura
  • Shigenobu Shibata
  • Tsuneyuki Yamamoto
  • Shigenori Watanabe
Article
N-benzyloxycarbonyl-thioprolythioprolinal-dimethylacetal (ZTTA) prolyl endopeptidase (PEP) PEP inhibitor basal forebrain lesion choline acetyltransferase step-through type passive avoidance test 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

REFERENCES

  1. 1.
    T. Yoshimoto, K. Ogita, M. Walter, M. Koida, and D. Tsuru. Post-proline cleaving enzyme. Biochim. Biophys. Acta 569:184–192 (1979).PubMedGoogle Scholar
  2. 2.
    N. Miura, S. Shibata, and S. Watanabe. Increase in the septal vasopressin content by prolyl endopeptidase inhibitors in rats. Neurosci. Lett. 196:128–130 (1995).PubMedGoogle Scholar
  3. 3.
    K. Toide, M. Shinoda, Y. Iwamoto, T. Fujiwara, K. Okamiya, and A. Uemura. A novel prolyl endopeptidase inhibitor, JTP-4819, with potential for treating Alzheimer's disease. Behav. Brain Res. 83:147–151 (1997).PubMedGoogle Scholar
  4. 4.
    D. L. Price, P. J. Whitehouse, R. G. Struble, A. W. Clark, J. T. Coyle, M. R. Delong, and J. C. Hedreen. Basal forebrain cholinergic systems in Alzheimer's disease and related dementias. Neurosci. Comment 1:84–92 (1982).Google Scholar
  5. 5.
    M. V. Johnston, M. McKinney, and J. T. Coyle. Evidence for a cholinergic projection to neocortex from neurons in basal forebrain. Proc. Natl. Acad. Sci. U.S.A. 76:5392–5396 (1979).PubMedGoogle Scholar
  6. 6.
    M. V. Johnston, M. McKinney, and J. T. Coyle. Neocortical cholinergic innervation: a description of extrinsic and intrinsic components in the rat. Exp. Brain Res. 43:159–172 (1981).PubMedGoogle Scholar
  7. 7.
    Y. Shishido, M. Furushiro, S. Tanabe, S. Nishiyama, S. Hashimoto, M. Ohno, T. Yamamoto, and S. Watanabe. ZTTA, a post proline cleaving enzyme inhibitor, improves cerebral ischemia-induced deficits in a three-panel runway task in rats. Pharmacol. Biochem. Behav. 55:333–338 (1996).PubMedGoogle Scholar
  8. 8.
    G. Paxinos and C. Watson. The rat brain in stereotaxic coordinates, Academic Press, New York, 1982.Google Scholar
  9. 9.
    M. Miyamoto, S. Narumi, A. Nagaoka, and J. T. Coyle. Effects of continuous infusion of cholinergic drugs on memory impairment in rats with basal forebrain lesions. J. Pharmacol. Exp. Ther. 248:825–835 (1989).PubMedGoogle Scholar
  10. 10.
    S. Nakamura, Y. Tani, Y. Maezono, T. Ishihara, and T. Ohno. Learning deficits after unilateral AF64A lesions in the rat basal forebrain. Pharmacol. Biochem. Behav. 42:119–130 (1992).PubMedGoogle Scholar
  11. 11.
    F. A. Fonnum. Rapid radiochemical method for the determination of choline acetyltransferase. J. Neurochem. 24:407–409 (1975).PubMedGoogle Scholar
  12. 12.
    K. Toide, M. Shinoda, M. Takase, K. Iwata, and H. Yoshida. Effects of a novel thyrotropin-releasing hormone analogue, JTP-2942, on extracellular acetylcholine and choline levels in the rat frontal cortex and hippocampus. Eur. J. Pharmacol. 233:21–28 (1993).PubMedGoogle Scholar
  13. 13.
    H. Maegawa, N. Katsube, T. Okegawa, H. Aishita, and A. Kawasaki. Arginine-vasopressin fragment 4–9 stimulates the acetylcholine release in hippocampus of freely-moving rats. Life Sci. 51:285–293 (1992).PubMedGoogle Scholar
  14. 14.
    M. Tanaka, E. R. De Kloet, D. De Wied, and D. H. Versteeg. Arginine8-vasopressin affects catecholamine metabolism in specific brain nuclei. Life Sci. 20:1799–1808 (1977).PubMedGoogle Scholar

Copyright information

© Plenum Publishing Corporation 1998

Authors and Affiliations

  • Yoshiyuki Shishido
    • 1
  • Masayoshi Furushiro
    • 1
  • Shuichi Tanabe
    • 1
  • Akira Taniguchi
    • 2
  • Shusuke Hashimoto
    • 1
  • Teruo Yokokura
    • 1
  • Shigenobu Shibata
    • 3
  • Tsuneyuki Yamamoto
    • 2
  • Shigenori Watanabe
    • 2
  1. 1.Yakult Central Institute for Microbiological ResearchYaho, Kunitachi-shi, TokyoJapan
  2. 2.Department of Pharmacology, Faculty of Pharmaceutical SciencesKyushu UniversityFukuokaJapan
  3. 3.Department of Pharmacology, School of Human SciencesWaseda UniversityTokorozawa-shi, SaitamaJapan

Personalised recommendations