Cardiovascular Drugs and Therapy

, Volume 15, Issue 3, pp 205–207 | Cite as

Has Melatonin a Future as a Cardioprotective Agent?

  • D.J. Duncker
  • P.D. Verdouw
Editorial Board


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  1. 1.
    Reiter RJ, Tan DX, Qi W, et al. Pharmacology and physiology of melatonin in the reduction of oxidative stress in vivo. Biol Signals Recept 2000; 9: 160-171.Google Scholar
  2. 2.
    Bertuglia S, Marchiafava PL, Colantuoni A. Melatonin prevents ischemia reperfusion injury in hamster cheek pouch microcirculation. Cardiovasc Res 1996; 31: 947-952.Google Scholar
  3. 3.
    Konturek PC, Konturek SJ, Majka J, et al. Melatonin affords protection against gastric lesions induced by ischemiareperfusion possibly due to its antioxidant and mucosal microcirculatory effects. Eur J Pharmacol 1997; 322: 73-77.Google Scholar
  4. 4.
    Whittle BJ, Lopez-Belmonte J, Moncada S. Regulation of gastric mucosal integrity by endogenous nitric oxide: Interactions with prostanoids and sensory neuropeptides in the rat. Br J Pharmacol 1990; 99: 607-611.Google Scholar
  5. 5.
    Borlongan CV, Yamamoto M, Takei N, et al. Glial cell survival is enhanced during melatonin-induced neuroprotection against cerebral ischemia. Faseb J 2000; 14: 1307-1317.Google Scholar
  6. 6.
    Ustundag B, Kazez A, Demirbag M, et al. Protective effect of melatonin on antioxidative system in experimental ischemiareperfusion of rat small intestine. Cell Physiol Biochem 2000; 10: 229-236.Google Scholar
  7. 7.
    Blatt CM, Rabinowitz SH, Lown B. Central serotonergic agents raise the repetitive extrasystole threshold of the vulnerable period of the canine ventricular myocardium. Circ Res 1979; 44: 723-730.Google Scholar
  8. 8.
    Verrier RL. Neurochemical approaches to the prevention of ventricular fibrillation. Fed Proc 1986; 45: 2191-2196.Google Scholar
  9. 9.
    Tan DX, Manchester LC, Reiter RJ, et al. Ischemia/ reperfusion-induced arrhythmias in the isolated rat heart: Prevention by melatonin. J Pineal Res 1998; 25: 184-191.Google Scholar
  10. 10.
    Kaneko S, Okumura K, Numaguchi Y, et al. Melatonin scavenges hydroxyl radical and protects isolated rat hearts from ischemic reperfusion injury. Life Sci 2000; 67: 4101-112.Google Scholar
  11. 11.
    Lagneux C, Joyeux M, Demenge P, et al. Protective effects of melatonin against ischemia-reperfusion injury in the isolated rat heart. Life Sci 2000; 66: 503-509.Google Scholar
  12. 12.
    Bolli R. Oxygen-derived free radicals and myocardial reperfusion injury: An overview. Cardiovasc Drugs Ther 1991; 5(Suppl 2): 249-268.Google Scholar
  13. 13.
    Dave RH, Hale SL, Kloner RA. The effect of melatonin on hemodynamics, blood flow, and myocardial infarct size in a rabbit model of ischemia-reperfusion. J Cardiovasc Pharmacol Ther 1998; 3: 153-160.Google Scholar
  14. 14.
    Salie R, Harper I, Cillie C, et al. Melatonin protects against ischaemic-reperfusion myocardial damage. J Mol Cell Cardiol 2001; 33: 343-357.Google Scholar
  15. 15.
    Szarszoi O, Asemu G, Vanecek J, et al. Effects of melatonin on injury produced by ischemia and reperfusion injury of the rat heart. Cardiovasc Drugs Ther 2001; 15: 251-258.Google Scholar
  16. 16.
    Girotti L, Lago M, Ianovsky O, et al. Low urinary 6-sulphatoxymelatonin levels in patients with coronary artery disease. J Pineal Res 2000; 29: 138-142.Google Scholar
  17. 17.
    Vanden Hoek TL, Becker LB, Shao Z, et al. Reactive oxygen species released from mitochondria during brief hypoxia induce preconditioning in cardiomyocytes. J Biol Chem 1998; 273: 18092-18098.Google Scholar
  18. 18.
    Pain T, Yang XM, Critz SD, et al. Opening of mitochondrial K+ATP channels triggers the preconditioned state by generating free radicals. Circ Res 2000; 87: 460-466.Google Scholar
  19. 19.
    Forbes RA, Steenbergen C, Murphy E. Diazoxide-induced cardioprotection requires signaling through a redoxsensitive mechanism. Circ Res 2001 88: 802-809.Google Scholar

Copyright information

© Kluwer Academic Publishers 2001

Authors and Affiliations

  • D.J. Duncker
    • 1
  • P.D. Verdouw
    • 1
  1. 1.Experimental Cardiology, ThoraxcenterErasmus University RotterdamRotterdamThe Netherlands

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