Advertisement

Journal of Biological Physics

, Volume 27, Issue 1, pp 81–93 | Cite as

Novel Cholesteric Phase in Dispersions of Nucleic Acids due to Polymeric Chelate Bridges

  • V.L. Golo
  • E.I. Kats
  • Yu.S. Volkov
  • V.I. Salyanov
  • Yu.M. Yevdokimov
Article

Abstract

Physics, Moscow, RussiaWe consider cholesteric liquid-crystalline DNA dispersions, and show thatpolymeric (Dau-Cu) complexes, the so-called bridges, between pairs of DNA molecules may generate a super liquid-crystalline structure (BR-phase), charachterized by a soliton lattice of the spatial distribution of theorder parameter. The BR-phase could have a layered spatial structure andan abnormal optical activity that could have a bearing upon the intenseCD-band observed in DNA-dispersions.

dichroism DNA liquid crystal 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Livolant, F. and Leforestier, A.: Condensed Phases of DNA: Structures and Phase Transitions, Progr. Polym. 21 (1996), 1115–1164.Google Scholar
  2. 2.
    Yevdokimov, Yu.M., Salyanov, V.I., Spener, F. and Palumbo, M.: Adjustable Cross-Linking of Neighbouring DNA Molecules in Liquid-Crystalline Dispersions Through Daunomycin-Copper Polymeric Chelate Complexes, Int. J. Biol. Marcomolecules 19 (1996), 247–255.Google Scholar
  3. 3.
    Yevdokimov, Yu.M., Salyanov, V.I., Buligin, L.V., Dembo, A.T., Gedig, E., Spener, F. and Palumbo, M.: Liquid-Crystalline Structure of Nucleic Acids: Effect of Anthracycline Drugs and Copper Ions, J. Biomol. Struct. Dynamics 15 (1998), 97–105.Google Scholar
  4. 4.
    Yevdokimov, Yu.M., Salyanov, V.I., Mchedlishvili, B.V., Bykov, V.A., Spener, F. and Palumbo, M.: Molecular Construction based on Double-Stranded Nucleic Acids and Synthetic Polynucleotides for Use in an Integral Bioprobe, Sens. Syst. 13 (1999), 81–89.Google Scholar
  5. 5.
    Barthelemy-Clavey, V., Maurizot, J.C. and Sicard, P.J.: Etude Spectro-Scopique du Complexe ADN-Daunomycin, Biochimie 55 (1973), 859–868.Google Scholar
  6. 6.
    Fritsche, H. and Berg, H.: An Analysis of Equilibrium Kinetic and Structural Data of Anthracycline-DNA Interaction, Gazetta Chimica Italiana 117 (1987), 331–351.Google Scholar
  7. 7.
    Bell, M.J., Buchanan, G.W., Hollebone, B.R. and Jones, E.D.: Antitumor Activity at the Molecular Level: Binding Modes in Anthracycline-Dinucleotide Complexes as Determined by Optical Titration and Magnetic Circular Dichroism, Can. J. Chem. 60 (1982), 291–298.Google Scholar
  8. 8.
    Pigram, W.J., Fuller, W. and Hamilton, L.D.: Stereochemistry of Intercalation: Interaction of Daunomycin with DNA, Nature New Biol 235 (1972), 17–18.Google Scholar
  9. 9.
    Greenaway, F.T. and Dabrowiak, J.C.: The Binding of Copper Ions to Daunomycin and Aldriamycin, J. Inorg. Biochem. 16 (1982), 91–107.Google Scholar
  10. 10.
    Bustamante, C., Samori, B. and Builes, E.: Daunomycin Inverts the Long-Range Chirality of DNA Condensed States, Biochemistry 39 (1991), 5661–5666.Google Scholar
  11. 11.
    Philips, D.R. and Carlyle, G.: The Effects of Physiological Levels of Divalent Metal Ions on the Interaction of Daunomycin with DNA: Evidence of a Ternary Daunomycin-Cu2+-DNA Complex, Biochem. Pharmacol. 30 (1981), 2021–2023.Google Scholar
  12. 12.
    Mikelson, P. and Levinson, W.: Metal Ion Participation in Binding of Daunomycin, Daunomicinone, and Adriamycin to Nucleic Acids, Bioinorg. Chem. 9 (1978), 441–452.Google Scholar
  13. 13.
    de Gennes, P.G. and Prost, J.: The Physics of Liquid Crystals, Clarendon Press, Oxford, 1993.Google Scholar
  14. 14.
    Chandrasekhar, S.: Liquid Crystals, Cambridge University Press, New York, 1977.Google Scholar
  15. 15.
    de Gennes, P.G.: Nematic Liquid Crystalline Polymers, In: A. Ciferri, W.R. Krigbaum and R.B. Meyer (eds.), Polymer Liquid Crystals, Academic Press, New York, 1982, pp. 115–121.Google Scholar
  16. 16.
    Belyakov, V.A., Orlov, V.P., Semenov, S.V., Skuridin, S.G., Lordkipanitze, G.B., Chernukha, B.A. and Yevdokimov, Yu.M.: Some Features of Circular Dichroism Spectra of Liquid-Crystalline Dispersions of Double-Stranded DNA Molecules with Stained Compounds, Biophysics 41 (1996), 1044–1055.Google Scholar
  17. 17.
    Terentjev, E.M. and Warner, M.: Linear Hydrodynamics and Viscoelasticity of Nematic Elastomers, cond-mat/0101042, 4 Jan. 2001.Google Scholar

Copyright information

© Kluwer Academic Publishers 2001

Authors and Affiliations

  • V.L. Golo
    • 1
  • E.I. Kats
    • 2
  • Yu.S. Volkov
    • 1
  • V.I. Salyanov
    • 3
  • Yu.M. Yevdokimov
    • 3
  1. 1.Department of Mechanics and MathematicsMoscow UniversityMoscowRussia
  2. 2.Institute Laue – LangevinGrenoble, Cedex – 9France
  3. 3.Institute of Molecular BiologyRussian Academy of SciencesMoscowRussia

Personalised recommendations