Neurochemical Research

, Volume 26, Issue 7, pp 841–844 | Cite as

Bupivacaine Hydrochloride Induces Muscle Fiber Necrosis and Hydroxyl Radical Formation-Dimethyl Sulphoxide Reduces Hydroxyl Radical Formation

  • Nobuo Wakata
  • Hideki Sugimoto
  • Hiroaki Iguchi
  • Nobuatsu Nomoto
  • Masao Kinoshita


We induced acute skeletal muscle necrosis in rats using bupivacaine hydrochloride and found that both 2,5- and 2,3-dihydroxybenzoic acid significantly increased in skeletal muscle. A single administration of dimethyl sulphoxide, a free radical scavenger, significantly lowered concentrations of 2,5- and 2,3-dihydroxybenzoic acid. These results suggest that dimethyl sulphoxide is an effective hydroxyl radical scavenger and may be useful in the treatment of myopathy.

Bupivacaine hydrochloride hydroxyl radical dimethyl sulphoxide 


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Copyright information

© Plenum Publishing Corporation 2001

Authors and Affiliations

  • Nobuo Wakata
    • 1
  • Hideki Sugimoto
    • 1
  • Hiroaki Iguchi
    • 1
  • Nobuatsu Nomoto
    • 1
  • Masao Kinoshita
    • 1
  1. 1.Fourth Department of Internal MedicineToho University School of MedicineMeguro-ku, TokyoJapan

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