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Biogerontology

, Volume 2, Issue 3, pp 155–164 | Cite as

Effects of mild heat shocks at young age on aging and longevity in Drosophila melanogaster

  • Éric Le Bourg
  • Philippe Valenti
  • Patrice Lucchetta
  • François Payre
Article

Abstract

Young adult flies were submitted to heat shocks (37°C) ofvarious durations (5, 10, 20, 40 or 60 min daily) for 1, 2 or 3 weeks. Aslight longevity increase, in both sexes, was only observed with thelowest heat shock. Longer shocks had neutral or negative effects. Fliessubmitted to the procedure providing a longevity increase did not show adelayed behavioral aging but survived longer at 37°C thancontrol flies. This higher thermotolerance was not associated with anincreased hsp70 induction. The results are discussed in connection withhormesis and previous results showing that hypergravity, an other mildstress, increases longevity and delays behavioral aging: different mildstresses may have contrasting effects on aging and longevity.

aging heat-shock heat-shock proteins longevity locomotor activity thermotolerance Drosophila melanogaster hormesis 

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References

  1. Dahlgaard J, Loeschke V, Michalak P and Justesen J (1998) Induced thermotolerance and associated expression of the heat-shock protein Hsp70 in adult Drosophila melanogaster. Funct Ecol 12: 786–793Google Scholar
  2. Feany MB and Bender WW (2000) A Drosophila model of Parkinson's disease. Nature 404: 394–398PubMedGoogle Scholar
  3. Guerra D, Loeschke V and Cavicchi S (2000) Chromosomal and cytoplasmic analysis of heat shock resistance in natural populations of Drosophila melanogaster. Hereditas 132: 143–149Google Scholar
  4. Holloszy JO (1993) Exercise increases average longevity of female rats despite an increased food intake and no growth retardation. J Geront Biol Sci 48: B97-B100Google Scholar
  5. Khazaeli AA, Tatar M, Pletcher SD and Curtsinger JW (1997) Heat-induced longevity extension in Drosophila. I. Heat treatment, mortality, and thermotolerance. J Gerontol Biol Sci 52A: B48-B52Google Scholar
  6. Krebs RA and Loeschke V (1994a) Effects to exposure to short-term heat stress on fitness components in Drosophila melanogaster. J Evol Biol 7: 39–49Google Scholar
  7. Krebs RA and Loeschke V (1994b) Costs and benefits of activation of the heat-shock response in Drosophila melanogaster. Funct Ecol 8: 730–737Google Scholar
  8. Kuether K and Arking R (1999) Drosophila selected for extended longevity are more sensitive to heat shock. Age 22: 175–180Google Scholar
  9. Le Bourg E (1987) The rate of living theory. Spontaneous locomotor activity, aging and longevity in Drosophila melanogaster. Exp Gerontol 22: 359–369PubMedGoogle Scholar
  10. Le Bourg E and Minois N (1997) Increased longevity and resistance to heat shock in Drosophila melanogaster flies exposed to hypergravity. C R Acad Sci Paris 320: 215–221PubMedGoogle Scholar
  11. Le Bourg E and Minois N (1999) A mild stress, hypergravity exposure, postpones behavioral aging in Drosophila melanogaster. Exp Gerontol 34: 157–172PubMedGoogle Scholar
  12. Le Bourg E, Lints FA, Fresquet N and Bullens P (1993) Review. Hypergravity, aging, and longevity in Drosophila melanogaster. Comp Biochem Physiol A 105: 389–396Google Scholar
  13. Le Bourg E, Minois N, Bullens P and Baret P (2000) A mild stress due to hypergravity exposure at young age increases longevity in Drosophila melanogaster males. Biogerontology 1: 145–155PubMedGoogle Scholar
  14. Lithgow GJ (1996) Invertebrate gerontology: the age mutations of Caenorhabditis elegans. BioEssays 18: 809–815PubMedGoogle Scholar
  15. Lithgow GJ, White TM, Melov S and Johnson TE (1995) Thermotolerance and extended life-span conferred by single-gene mutations and induced by thermal stress. Proc Natl Acad Sci USA 92: 7540–7544PubMedGoogle Scholar
  16. Luckinbill LS (1998) Selection for longevity confers resistance to low-temperaure stress in Drosophla melanogaster. J Gerontol Biol Sci 53A: B147-B153Google Scholar
  17. Minois N (2000) Longevity and aging: beneficial effects of exposure to mild stress. Biogerontology 1: 15–29PubMedGoogle Scholar
  18. Minois N and Le Bourg E (1999) Resistance to stress as a function of age in Drosophila melanogaster living in hypergravity. Mech Ageing Dev 109: 53–64PubMedGoogle Scholar
  19. Minois N, Guinaudy MJ, Payre F and Le Bourg E (1999) HSP70 induction may explain the long-lasting resistance to heat of Drosophila melanogaster having lived in hypergravity. Mech Ageing Dev 109: 65–77PubMedGoogle Scholar
  20. Miquel J, Lundgren PR and Binnard R (1972) Negative geotaxis and mating behavior in control and gamma-irradiated Drosophila. Droso Infor Serv 60: 48Google Scholar
  21. Rattan SIS (2000) Ageing, gerontogenes and hormesis. Ind J Exp Biol 38: 1–5Google Scholar
  22. Sacher GA (1963) Effects of X-rays on the survival of Drosophila imagoes. Physiol Zool 36: 295–311Google Scholar
  23. Service PM, Hutchinson EW, MacKinley MD and Rose MR (1985) Resistance to environmental stress in Drosophila melanogaster selected for postponed senescence. Physiol Zool 58: 380–389Google Scholar
  24. Shaw PJ, Cirelli C, Greenspan RJ and Tononi G (2000) Correlates of sleep and waking in Drosophila melanogaster. Science 287: 1834–1837PubMedGoogle Scholar
  25. Velasquez JM, Sonoda S, Bugaisky G and Lindquist S (1983) Is the major Drosophila heat shock protein present in cells that have not been shocked? J Cell Biol 96: 286–290PubMedGoogle Scholar
  26. Vieira C, Pasyukova EG, Zeng ZB, Hackett JB, Lyman RF, Mackay TFC (2000) Genotype-environment interaction for quantitative trait loci affecting life span in Drosophila melanogaster. Genetics 154: 213–227PubMedGoogle Scholar

Copyright information

© Kluwer Academic Publishers 2001

Authors and Affiliations

  • Éric Le Bourg
    • 1
  • Philippe Valenti
    • 2
  • Patrice Lucchetta
    • 1
  • François Payre
    • 2
  1. 1.Laboratoire d'Éthologie et de Cognition Animale, F.R.E. C.N.R.S. no. 2382Université Paul-SabatierToulouse cedex 4France (e-mail:
  2. 2.Centre de Biologie du Développement, U.M.R. C.N.R.S. no. 5547Université Paul-SabatierToulouse cedex 4France

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