Biomedical Microdevices

, Volume 3, Issue 3, pp 245–254 | Cite as

Design and Fabrication of CD-like Microfluidic Platforms for Diagnostics: Microfluidic Functions

  • Marc J. Madou
  • L. James Lee
  • Sylvia Daunert
  • Siyi Lai
  • Chih-Hsin Shih


In this paper, the design of a polymer based microfluidic compact disk (CD) platform is presented. Several microfluidic functions such as flow sequencing, cascade micro-mixing, and capillary metering can be integrated into the CD by balancing the centrifugal force and the capillary force. These functions are demonstrated experimentally. For flow sequencing, a two-point calibration design is used as an example to show how the release and flow of fluids can be precisely controlled by the rotation speed of the CD. For cascade micro-mixing, a typical application is reconstituting lyophilized protein. A simple metering technique based on bubble snap-off in the two-phase flow is also described.

microfluidic centrifugal force capillary force CD platform flow sequencing micro-mixing sample metering 


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Copyright information

© Kluwer Academic Publishers 2001

Authors and Affiliations

  • Marc J. Madou
    • 1
  • L. James Lee
    • 2
  • Sylvia Daunert
    • 3
  • Siyi Lai
    • 2
  • Chih-Hsin Shih
    • 2
  1. 1.Department of Materials Science and EngineeringUSA
  2. 2.Department of Chemical EngineeringThe Ohio State University Columbus
  3. 3.Department of ChemistryUniversity of KentuckyUSA

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