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Biomedical Microdevices

, Volume 3, Issue 3, pp 245–254 | Cite as

Design and Fabrication of CD-like Microfluidic Platforms for Diagnostics: Microfluidic Functions

  • Marc J. Madou
  • L. James Lee
  • Sylvia Daunert
  • Siyi Lai
  • Chih-Hsin Shih
Article

Abstract

In this paper, the design of a polymer based microfluidic compact disk (CD) platform is presented. Several microfluidic functions such as flow sequencing, cascade micro-mixing, and capillary metering can be integrated into the CD by balancing the centrifugal force and the capillary force. These functions are demonstrated experimentally. For flow sequencing, a two-point calibration design is used as an example to show how the release and flow of fluids can be precisely controlled by the rotation speed of the CD. For cascade micro-mixing, a typical application is reconstituting lyophilized protein. A simple metering technique based on bubble snap-off in the two-phase flow is also described.

microfluidic centrifugal force capillary force CD platform flow sequencing micro-mixing sample metering 

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References

  1. 1.
    A. Manz, C.S. Effenhauser, N. Burggraf, E.J.M. Verpoorte, D.E. Raymond, and H.M. Widmer, Analysis Mag. 22, M25 (1994).Google Scholar
  2. 2.
    M.J. Madou, Fundamental of Microfabrication (CRC Press, Boca Raton, 1997).Google Scholar
  3. 3.
    M. Freemantle, Chem. Eng. News 27, (February 22, 1999).Google Scholar
  4. 4.
    P. Gravesen, J. Branebjerg, and O.S. Jensen, J. Micromech. Microeng. 3, 168 (1993).Google Scholar
  5. 5.
    J.C. Mcdonald, D.C. Duffy, J.R. Anderson, D.T. Chiu, H. Wu, O.J.A. Schueller, and G.M. Whitesides, Electrophoresis 21, 27 (2000).Google Scholar
  6. 6.
    M.J. Madou and G.J. Kellogg, SPIE Proceedings, 3259, 80, San Jose, CA (1998).Google Scholar
  7. 7.
    L.J. Lee, M.J. Madou, K.W. Koelling, S. Daunert, S. Lai, C.G. Koh, Y.-J. Juang, Y. Lu, and L. Yu, Biomedical Microdevices 3(4) (2001, in press).Google Scholar
  8. 8.
    M.J. Madou, Y. Lu, S. Lai, L.J. Lee, and S. Daunert, Micro Total Analysis Systems, 565 (2000).Google Scholar
  9. 9.
    J.B. Findlay, S. Atwood, M.L. Bergmeyer, J. Chemelli, K. Christy, T. Cummins, W. Donish, T. Ekeze, J. Falvo, and D. Patterson, Clin. Chem. 39, 1927 (1993).Google Scholar
  10. 10.
    R.M. Moroney, R.M. White, and R.T. Howe, IEEE 1990 Ultrasonics Symposium Proceedings, 355, Honolulu, HI (1990).Google Scholar
  11. 11.
    D.J. Harrison, Z. Fan, K. Fluri, and K. Seiler, Solid State Sensor & Actuator Workshop, 21, Hilton Head Island, SC (1994).Google Scholar
  12. 12.
    C.S. Effenhauser, G.J.M. Bruin, A. Paulus, and M. Ehrat, Anal. Chem. 69, 3451 (1997).Google Scholar
  13. 13.
    J.R. Webster, M.A. Burns, and C.H. Mastrangelo, Annu. Int. Conf. Micro Electro Mech. Syst., Proc., 13th, 306 (2000).Google Scholar
  14. 14.
    M. Deshpande, K.B. Greiner, J. West, J.R. Gilber, L. Bousse, and A. Minalla, Solid State Sensor and Actuator Workshop, 128 (2000).Google Scholar
  15. 15.
    H.C. Chang, D.T. Leighton, A.E. Miller, A.E. Ostafin, and P.V. Takhistov, AIChE Annual Meeting, Los Angeles, CA, (2000).Google Scholar
  16. 16.
    A. Richter, A. Plettner, K. Hoffmann, and H. Sandmaier, IEEE Micro Electro Mechanical Systems (MEMS'91), 271, Nara (1991).Google Scholar
  17. 17.
    S.C. Jacobson, R. Hergenroder, A.W. Moore, and J.M. Ramsey, Solid State Sensor and Actuator Workshop, 65, Hilton Head Island, SC (1994).Google Scholar
  18. 18.
    E. Colgate and H. Matsumoto, J. Vac, Sci. Technol. A8(4), 3625 (1990).Google Scholar
  19. 19.
    H.J. Zheng and P.K. Dasgupta, Anal. Chem. 66, 3997 (1994).Google Scholar
  20. 20.
    T.S. Sammarco and M.A. Burns, AIChE J. 45(2), 350 (1999).Google Scholar
  21. 21.
    T.K. Jun and C.-J. Kim, J. Appl. Phys. 83(11, Pt. 1), 5658 (1998).Google Scholar
  22. 22.
    I. Kaetsu, K. Uchida, H. Shindo, S. Gomi, and K. Sutani, Radiation Phys. Chem. 55, 193 (1999).Google Scholar
  23. 23.
    R.H. Liu, Q. Yu, J.M. Bauer, J.S. Moore, and D.J. Beebe, Solid State Sensor & Actuator Workshop, 222, Hilton Head Island, SC, June (2000).Google Scholar
  24. 24.
    X. Cao, S. Lai, and L.J. Lee, Biomedical Microdevices 3(2), 109 (2001).Google Scholar
  25. 25.
    S.C. Jacobson, S.V. Ermakov, and J.M. Ramsey, Anal. Chem. 71(15), 3273 (1999).Google Scholar
  26. 26.
    J. Zeng, D. Banerjee, M. Deshpande, J. Gilbert, D.C. Duffy, and G.J. Kellogg, Micro Total Analysis Systems, 579 (2000).Google Scholar
  27. 27.
    D.C. Duffy, H.L. Gills, J. Lin, N.F. Sheppard, and G.J. Kellogg, J. Anal. Chem. 71, 4669 (1999).Google Scholar
  28. 28.
    M.J. Madou, Y. Lu, S. Lai, Y.-J. Juang, L.J. Lee, and S. Daunert, Solid State Sensor & Actuator Workshop, 191, Hilton Head Island, SC, June (2000).Google Scholar
  29. 29.
    J. Branebjerg, P. Gravesen, J.P. Krog, and C.R. Nielsen, Proceedings IEEE Micro Electro Mechanical Systems (MEMS), 441 (1996).Google Scholar
  30. 30.
    M. Koch, D. Chatelain, A.G.R. Evans, and A. Brunnschweiler, J. Micromech. Microeng. 8, 123 (1998).Google Scholar
  31. 31.
    N. Schwesinger, T. Frank, and H. Wurmus, J. Micromech. Microeng. 6(1), 99 (1996).Google Scholar
  32. 32.
    M. Elwenspoek, T.S.J. Lammerink, R. Miyake, and J.H.J. Fluitman, J. Micromech. Microeng. 4, 227-245 (1994).Google Scholar
  33. 33.
    P. Woias, K. Hauser, and E. Yacoub-george, Micro Total Analysis Systems, 277 (2000).Google Scholar
  34. 34.
    J. Evans, D. Liepmann, and A.P. Pisano, Proceedings IEEE Micro Electro Mechanical Systems (MEMS), 96-101 (1997).Google Scholar
  35. 35.
    J-W Choi and C.H. Ahn, Solid-State Sensor and Actuator Workshop, 52, Hilton Head, June (2000).Google Scholar
  36. 36.
    M. Yi and H.H. Bau, ASME (MEMS) Proceedings, 489 (2000).Google Scholar
  37. 37.
    K. Handique, D.T. Burke, C.H. Mastrangelo, and M.A. Burns, Anal. Chem. 72, 4100 (2000).Google Scholar
  38. 38.
    T.C. Ransohoff, P.A. Gauglitz, and C.J. Radke, AIChE J. 33(5), 753 (1987).Google Scholar
  39. 39.
    K.T. Chambers and C.J. Radke, Interfacial Phenomena in Petroleum Recovery, N.R. Morrow, eds. (Dekker Publishers, New York, 1991).Google Scholar

Copyright information

© Kluwer Academic Publishers 2001

Authors and Affiliations

  • Marc J. Madou
    • 1
  • L. James Lee
    • 2
  • Sylvia Daunert
    • 3
  • Siyi Lai
    • 2
  • Chih-Hsin Shih
    • 2
  1. 1.Department of Materials Science and EngineeringUSA
  2. 2.Department of Chemical EngineeringThe Ohio State University Columbus
  3. 3.Department of ChemistryUniversity of KentuckyUSA

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