Russian Chemical Bulletin

, Volume 50, Issue 5, pp 820–822 | Cite as

Hydrolysis of some imidazole, benzimidazole, and 1,2,3-benzotriazole derivatives according to HPLC and NMR diffusimetry data

  • Yu. L. Polyakova
  • A. V. Bulanova
  • R. Sh. Vartapetyan
Article
  • 221 Downloads

Abstract

Hydrolysis of 1-mesylimidazole, 1-mesylbenzotriazole, and 1-tosylbenzimidazole was studied by reversed-phase HPLC and pulsed field gradient NMR diffusimetry. The hydrolysis rate constants and half reaction times were determined. The self-diffusion coefficients of the substances in aqueous solutions were measured. The reversed-phase HPLC data agree well with those of NMR diffusimetry.

hydrolysis hydrolysis rate constant self-diffusion coefficients biologically active substances reversed-phase HPLC NMR diffusimetry 

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Copyright information

© Plenum Publishing Corporation 2001

Authors and Affiliations

  • Yu. L. Polyakova
    • 1
  • A. V. Bulanova
    • 1
  • R. Sh. Vartapetyan
    • 2
  1. 1.Samara State UniversitySamaraRussian Federation
  2. 2.Institute of Physical ChemistryRussian Academy of SciencesMoscowRussian Federation

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