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Biomimetic coatings on titanium: a crystal growth study of octacalcium phosphate

  • F. Barre`reEmail author
  • P. Layrolle
  • C.A. van Blitterswijk
  • K. de Groot
Article

Abstract

The biomimetic approach allows the coating of metal implants with different calcium-phosphate (Ca-P) phases. Films elaborated at physiological conditions exhibited structures closely resembling those of bone mineral. For instance, octacalcium phosphate (OCP, Ca8(HPO4)2(PO4)4 · 5H2O) crystals have been deposited on titanium through a two-step procedure. After cleaning and etching, Ti6Al4V plates were immersed for 24 h into a simulated body fluid (SBF1). A thin amorphous carbonated Ca-P layer precipitated on the metal substrate. Secondly, these thinly Ca-P coated titanium substrates were immersed for 48 h into another simulated body fluid (SBF2). The thin amorphous carbonated Ca-P layer induced the fast precipitation of a second Ca-P layer of 55 μm in thickness composed of OCP crystals. The measurements of Ca and P concentrations versus soaking time in SBF2 showed that the carbonated Ca-P layer partially dissolved before the deposition of the OCP coating. X-ray diffraction (XRD) revealed that OCP crystals grew epitaxially on the substrate. OCP is known to be one of the precursors during the bone mineralization process, thereby, this new generation of biomimetic coatings are promising for orthopedic surgery. © 2001 Kluwer Academic Publishers

Keywords

Titanium Orthopedic Surgery Simulated Body Fluid Mineralization Process Metal Substrate 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    R. G. T. Geesink and N. H. M. Hoefnagels, J. Bone Joint Surg. 77B (1995) 534.Google Scholar
  2. 2.
    T. Kokubo, H. Kushitani, Y. Abe and T. Yamamuro, Bioceramics 2 (1990) 235.Google Scholar
  3. 3.
    P. Layrolle, C. A. Van Blitterswijk and K. De Groot, Bioceramics 11 (1998) 465.Google Scholar
  4. 4.
    F. Barrere, P. Layrolle, C. A. Van Blitterswijk, K. De Groot, Mat. Res. Symp. Proc. 599 (2000) 135.Google Scholar
  5. 5.
    P. Li, I. Kanganesniemi, K. De Groot and T. Kokubo, J. Am. Ceram. Soc. 77 (1994) 1307.Google Scholar
  6. 6.
    T. Peltola, M. Patsi, H. Rahiala, I. Kangasniemi and A. Yli-Urpo, J. Biomed. Mater. Res. 41 (1998) 504.Google Scholar
  7. 7.
    P. Li and P. Ducheyne, J. Biomed. Mater. Res. 41 (1998) 341.Google Scholar
  8. 8.
    R. Z. Legeros, in “Biological and Synthetic Apatites in Hydroxyapatite and Related Materials” edited by P. W. Brown and B. Constanz (CRC Press, Roca-Batton, 1994) p. 3.Google Scholar
  9. 9.
    W. E. Brown, Nature 196 (1962) 1048.Google Scholar
  10. 10.
    F. Sugihara, H. Oonishi, S. Kushitani, N. Iwaki, Y. Mandai, K. Minamigawa, E. Tshuji, M. Yoshikawa and T. Toda, Bioceramics 8 (1995) 89.Google Scholar
  11. 11.
    O. Suzuki, M. Nakamura, Y. Miyasaka, M. Kagayama and M. Sakurai, Tohoku J. Exp. Med. 164 (1991) 37-50.Google Scholar
  12. 12.
    F. Barrere, P. Layrolle, C. A. Van Blitterswijk and K. De Groot, Bone 25 (1999) 107S.Google Scholar
  13. 13.
    B. O. Fowler, M. Markovic and W. E. Brown, Chem. Mater 15 (1993) 1417.Google Scholar
  14. 14.
    Joint Comity for Powder Diffraction Standards, OCP 26-1056 (1992).Google Scholar
  15. 15.
    E. D. Eanes and J. L. Meyer, Calcif. Tiss. Res. 23 (1977) 259.Google Scholar
  16. 16.
    E. C. Moreno and K. Varughese, J. Crystal Growth 53 (1981) 20.Google Scholar
  17. 17.
    R. Z. Legeros, R. Kijkowska and J. P. Legeros, Scan. Elec. Micros. IV (1984) 1771.Google Scholar
  18. 18.
    P. T. Cheng and K. P. H. Pritzker, Calcif. Tissues Int. 35 (1983) 596.Google Scholar
  19. 19.
    M. Hjima, H. Kamemizu, N. Wakamatsu, T. Goto, Y. Doi and Y. Moriwaki, J. Crystal Growth 112 (1991) 467.Google Scholar
  20. 20.
    M. J. J. M. Van Kemenade and P. L. De Bruijn, J. Colloid Interface Sci. 118 (1987) 564Google Scholar
  21. 21.
    J. C. Heughebaert and G. H. Nancollas, J. Phys. Chem. 88 (1984) 2478.Google Scholar
  22. 22.
    R. Z. Le Geros, G. Daculsi, I. Orly, T. Abergas and W. Torres, Scan. Micros. 1 (1989) 129.Google Scholar

Copyright information

© Kluwer Academic Publishers 2001

Authors and Affiliations

  • F. Barre`re
    • 1
    • 2
    Email author
  • P. Layrolle
    • 1
  • C.A. van Blitterswijk
    • 1
    • 2
  • K. de Groot
    • 1
    • 3
  1. 1.IsoTis B.V.BilthovenThe Netherlands
  2. 2.iBMETwente UniversityThe Netherlands
  3. 3.BRGLeiden UniversityThe Netherlands

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