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Cancer Causes & Control

, Volume 12, Issue 8, pp 673–681 | Cite as

GSTP1 polymorphisms and gastric cancer in a high-risk Chinese population

  • Veronica Wendy Setiawan
  • Zuo-Feng Zhang
  • Guo-Pei Yu
  • Qing-Yi Lu
  • Yong-Liang Li
  • Ming-Lan Lu
  • Ming-Rong Wang
  • Chun Hua Guo
  • Shun-Zhang Yu
  • Robert C Kurtz
  • Chung-Cheng Hsieh
Article

Abstract

Objectives: In a population-based case–control study in Yangzhong, China, we investigated the relationship between genetic polymorphisms of GSTP1 and susceptibility to gastric cancer and its premalignant lesion, chronic gastritis. The possible gene–gene interactions between GSTP1 polymorphisms and GSTM1, GSTT1 genes were explored.

Methods: Epidemiologic data were collected by standard questionnaire from 133 gastric cancer cases, 166 chronic gastritis cases, and 433 cancer-free population controls. Blood samples for Helicobacter pylori and molecular marker assays were collected from 84 gastric cancer cases, 146 chronic gastritis, and 429 population controls. GSTP1 polymorphisms were determined by the PCR-RFLP method and H. pylori infection was measured by the ELISA method. Associations between certain GSTP1 genotypes and both gastric cancer and chronic gastritis were assessed by odds ratios (ORs) and 95% confidence intervals (CIs) derived from logistic regression.

Results: The distributions of three GSTP1 genotypes, Ile/Ile, Ile/Val, and Val/Val, were similar in gastric cancer cases, chronic gastritis, and controls. After adjusting for age, gender, education, body mass index, pack-year of smoking, alcohol drinking, H. pylori infection, salt and fruit intakes, the adjusted ORs of Val/Val were 1.3 (95% CI: 0.1–11.2) for gastric cancer and 0.9 (95% CI: 0.2–4.8) for chronic gastritis. Combining the Val alleles (Val/Val and Ile/Val) into one group, no association was observed between GSTP1 and both gastric cancer and chronic gastritis. In addition, the allelism at the GSTP1 locus did not increase gastric cancer and chronic gastritis risks associated with the GSTM1 or GSTT1 genotypes.

Conclusion: Our data suggest that the GSTP1 genotype seems not to be associated with the risk of gastric cancer and chronic gastritis in a high-risk Chinese population.

chronic gastritis gastric cancer GSTP1 risk factors 

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Copyright information

© Kluwer Academic Publishers 2001

Authors and Affiliations

  • Veronica Wendy Setiawan
    • 1
  • Zuo-Feng Zhang
    • 1
  • Guo-Pei Yu
    • 2
  • Qing-Yi Lu
    • 3
  • Yong-Liang Li
    • 4
  • Ming-Lan Lu
    • 5
  • Ming-Rong Wang
    • 6
  • Chun Hua Guo
    • 6
  • Shun-Zhang Yu
    • 7
  • Robert C Kurtz
    • 8
  • Chung-Cheng Hsieh
    • 9
  1. 1.Department of EpidemiologyUCLA School of Public Health, and Jonsson Comprehensive Cancer CenterLos AngelesUSA
  2. 2.Biostatistics and Epidemiology ServiceNew York Eye and Ear InfirmaryNew YorkUSA
  3. 3.Center for Human NutritionUCLA School of MedicineLos AngelesUSA
  4. 4.School of Public HealthColumbia UniversityNew YorkUSA
  5. 5.Department of PathologyMemorial Sloan-Kettering Cancer CenterNew YorkUSA
  6. 6.Yangzhong County Anti-Epidemic StationYangzhong CountyPR of China
  7. 7.Department of Epidemiology, School of Public HealthShanghai Medical UniversityShanghaiPR of China
  8. 8.Gastroenterology and Nutrition Service, Department of MedicineMemorial Sloan-Kettering Cancer CenterNew YorkUSA
  9. 9.Division of Biostatistics and EpidemiologyUniversity of Massachusetts Cancer CenterWorcesterUSA

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