Pharmacy World and Science

, Volume 23, Issue 3, pp 122–122 | Cite as

Pre‐emptive metoclopramide and ondansetron for nausea and vomiting associated with iloprost infusions

  • Chris Roome
  • John Thompson
Article

Abstract

Objective: To assess the effectiveness of ondansetron in relieving symptoms of nausea and vomiting which were refractory to metoclopramide and cyclizine, in a patient receiving iloprost infusions.Method: Case observation in a series of 7 infusions.Results: Ondansetron reduced WHO symptom scores of vomiting from Grade 2 to Grade 0. Symptoms of nausea were abolished on some occasions.Conclusion: Ondansetron was found to be effective at abolishing symptoms of vomiting and partially effective against symptoms of nausea. It may prove to be a useful treatment modality to allow the patient to tolerate further infusions of iloprost where nausea and vomiting has failed to respond to other agents.

Iloprost Metoclopramide Ondansetron Prostanoids Vomiting 

References

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    Lawhorn S, Lawhorn C, Davison C. Ondansetron eliminates vomiting associated with prostacyclin in a patient awaiting lung transplantation. J Heart Lung Transplant 1997;16:472-3Google Scholar
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    Fisch A, Tobasch K, Veit K, Meyer J, Darius H. Prostacyclin receptor desensitisation is a reversible phenomenon in human platelets. Circulation 1997:96,756-60Google Scholar

Copyright information

© Kluwer Academic Publishers 2001

Authors and Affiliations

  • Chris Roome
    • 1
  • John Thompson
    • 1
  1. 1.Royal Devon & Exeter Hospital (Wonford)Exeter, EnglandUK

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