Glycoconjugate Journal

, Volume 17, Issue 7–9, pp 543–551

Affinity enhancement by multivalent lectin–carbohydrate interaction

  • Reiko T. Lee
  • Yuan C. Lee

DOI: 10.1023/A:1011070425430

Cite this article as:
Lee, R.T. & Lee, Y.C. Glycoconj J (2000) 17: 543. doi:10.1023/A:1011070425430


The binding of simple carbohydrate ligands by proteins often requires affinity enhancement to attain biologically relevant strength. This is especially true for endocytotic receptors and the molecules that engage in the first-line of defense. For such purposes, nature often utilizes a mode of affinity enhancement that arises from multiple interactions between the binding proteins and the carbohydrate ligands, which we term glycoside cluster effect. In this review article we give a number of examples and describe important factors in the multi-valent interactions that govern the degree of affinity enhancement.

glycoside cluster effect multi-valent interaction C-type lectins affinity enhancement 

Copyright information

© Kluwer Academic Publishers 2000

Authors and Affiliations

  • Reiko T. Lee
    • 1
  • Yuan C. Lee
    • 1
  1. 1.Department of BiologyJohns Hopkins UniversityBaltimoreUSA

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