Pharmaceutical Research

, Volume 18, Issue 5, pp 694–701

Lipophilicity Behaviour of the Zwitterionic Antihistamine Cetirizine in Phosphatidylcholine Liposomes/Water Systems

  • Georgette Plemper van Balen
  • Giulia Caron
  • Giuseppe Ermondi
  • Alessandra Pagliara
  • Teresa Grandi
  • Géraldine Bouchard
  • Roberta Fruttero
  • Pierre–Alain Carrupt
  • Bernard Testa
Article

Abstract

Purpose. The partitioning of cetirizine in a phosphatidylcholine liposomes/water system was compared with that of hydroxyzine and acrivastine to gain insight into the mechanisms of interaction of its various electrical species with membranes.

Methods. The lipophilicity profiles of the compounds were obtained from equilibrium dialysis and potentiometry, and compared with changes in NMR relaxation rates.

Results. The neutral form of hydroxyzine interacted mainly via hydrophobic interactions with the bilayer lipid core of the membrane, whereas for the cationic form both hydrophobic and electrostatic interactions were involved. Zwitterionic and anionic cetirizine were less lipophilic than its cation, which behaved like the corresponding species of hydroxyzine. Zwitterionic cetirizine interacted more by weak electrostatic interactions with the polar headgroups of phospholipids than by hydrophobic interactions with the membrane interior. The lipophilicity of its anion reflected the balance of repulsive electrostatic interactions between the carboxylate and phosphate groups and the hydrophobic interactions with the lipid core.

Conclusion. The study confirms that various mechanisms influence the interaction of solutes with liposomes. Combining experimental techniques and using suitable reference compounds proves useful.

cetirizine phosphatidylcholine liposomes equilibrium dialysis, potentiometry NMR distribution profiles lipophilicity 

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Copyright information

© Plenum Publishing Corporation 2001

Authors and Affiliations

  • Georgette Plemper van Balen
    • 1
  • Giulia Caron
    • 1
    • 2
  • Giuseppe Ermondi
    • 3
  • Alessandra Pagliara
    • 1
  • Teresa Grandi
    • 1
  • Géraldine Bouchard
    • 1
  • Roberta Fruttero
    • 4
  • Pierre–Alain Carrupt
    • 1
  • Bernard Testa
    • 1
  1. 1.Institut de Chimie Thérapeutique, Section de PharmacieUniversité de LausanneLausanneSwitzerland
  2. 2.Dipartimento di Scienza e Tecnologia del FarmacoUniversità di TorinoTorinoItaly
  3. 3.DISCAFF, Università del Piemonte OrientaleNovara
  4. 4.Dipartimento di Scienza e Tecnologia del FarmacoUniversità di TorinoTorinoItaly

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