European Journal of Epidemiology

, Volume 16, Issue 10, pp 899–905 | Cite as

A cohort study of nutritional factors and endometrial cancer

  • Meera G. Jain
  • Thomas E. Rohan
  • Geoffrey R. Howe
  • Anthony B. Miller


To evaluate the role of nutritional factors in the etiology of endometrial cancer, we performed a case-cohort analysis using data from women enrolled in the National Breast Screening Study in Canada from 1980 to 1985. For this analysis, a subcohort was constructed by selecting a 10% random sample from the 56,837 women in the dietary cohort. Cases were the 221 women diagnosed with incident adenocarcinoma of the endometrium during follow-up to December 31, 1993 and ascertained by record linkage to the Canadian Cancer Database. Information on usual diet at enrolment and other epidemiological variables was collected by means of self-administered questionnaires. Hazard ratios were obtained from proportional hazards regression models, with estimation of robust standard errors. We found a strong association of endometrial cancer with body mass index >25 kg/m2 (hazard ratio 2.72, 95% CI: 2.06–3.50). Endometrial cancer risk was not associated significantly with intakes of total energy, carbohydrates, proteins, total fat and major fatty acids, total dietary fiber and various types of fibers, vitamin C, E and A, folic acid, β-carotene, lutein, or cryptoxanthin. Some decrease in risk was noted with relatively high intakes of saturated fat, animal fat or lycopene. The associations observed in the study were independent of total energy intake and most non-dietary risk factors. The study suggests that dietary intakes of energy and most major nutrients are not related to the risk of endometrial cancer among Canadian women.

Diet Endometrial cancer Macro-nutrients Micro-nutrients Obesity 


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Copyright information

© Kluwer Academic Publishers 2000

Authors and Affiliations

  • Meera G. Jain
    • 1
    • 2
  • Thomas E. Rohan
    • 1
  • Geoffrey R. Howe
    • 3
  • Anthony B. Miller
    • 1
  1. 1.Department of Public Health SciencesUniversity of TorontoTorontoCanada
  2. 2.Health Information SectionToronto Public HealthTorontoCanada
  3. 3.Division of EpidemiologyColumbia UniversityUSA

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