Neurochemical Research

, Volume 26, Issue 3, pp 187–190

Distribution of [3H]GR65630 Binding in Human Brain Postmortem

  • Donatella Marazziti
  • Laura Betti
  • Gino Giannaccini
  • Alessandra Rossi
  • Irene Masala
  • Stefano Baroni
  • Giovanni B. Cassano
  • Antonio Lucacchini
Article

Abstract

We investigated the distribution of serotonin (5-HT) receptors of type 3 (5-HT3) in human brain areas, by means of the the specific binding of [3H]GR65630. The brains were obtained during autoptic sessions from 6 subjects. Human brain membranes and the binding of [3H]GR65630 were carried out according to standardized methods. The highest density (Bmax ± 6 SD, fmol/mg protein) of [3H]GR65630 binding sites was found in area postrema (13.1 ± 9.7), followed at a statistically lower level, by nucleus tractus solitarius (6.7 ± 3.4), nervus vagus (5.5 ± 2.1), striatum (4.8 ± 2.4) with a progressive decrease in amygdala, olivar nuclei, hippocampus, olfactory bulbus and prefrontal cortex, and then by the other cortical areas and the cerebellum, where no binding was detected. These observations extend previous findings on the distribution of 5-HT3 receptors and confirm interspecies variations that might explain the heterogeneous properties of 5-HT3 receptors in different animals.

Serotonin serotonin receptors of type 3 human brain postmortem [3H]GR65630 binding 

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Copyright information

© Plenum Publishing Corporation 2001

Authors and Affiliations

  • Donatella Marazziti
    • 1
  • Laura Betti
    • 1
  • Gino Giannaccini
    • 1
  • Alessandra Rossi
    • 1
  • Irene Masala
    • 1
  • Stefano Baroni
    • 1
  • Giovanni B. Cassano
    • 1
  • Antonio Lucacchini
    • 1
  1. 1.Dipartimento di Psichiatria, Neurobiologia, Farmacologia e Biotecnologie, Clinica PsichiatricaUniversity of PisaItaly

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