Journal of Behavioral Medicine

, Volume 24, Issue 3, pp 219–229

Differences in Functional Immune Responses of High vs. Low Hardy Healthy Individuals

  • Christyn L. Dolbier
  • Robert R. Cocke
  • Jenn A. Leiferman
  • Mary A. Steinhardt
  • Steven J. Schapiro
  • Pramod N. Nehete
  • Jaine E. Perlman
  • Jagannadha Sastry
Article

DOI: 10.1023/A:1010762606006

Cite this article as:
Dolbier, C.L., Cocke, R.R., Leiferman, J.A. et al. J Behav Med (2001) 24: 219. doi:10.1023/A:1010762606006

Abstract

An association between the personality trait of hardiness and immune responses was explored. Blood samples were collected from 21 healthy individuals under nonstressful conditions, who had either high or low levels of hardiness. Functional immune assays tested for natural killer (NK) cell activity and proliferation responses to Candida albicans (Candida), purified protein derivative from Mycobacterium tuberculosis (PPD), lipopolysaccharide (LPS), concanavalin A (Con A), and Staphylococcus enterotoxin A (Staph A). Differences between high and low hardy groups on these immune responses were examined using Bonferroni adjusted independent t-tests. Results revealed significant differences between the groups for Candida, PPD, Con A, and Staph A. In all instances, the high hardy group had larger mean proliferative responses than the low hardy group. Implications of the study as well as avenues for future research are discussed.

hardiness immune function psychoneuroimmunology 

Copyright information

© Plenum Publishing Corporation 2001

Authors and Affiliations

  • Christyn L. Dolbier
  • Robert R. Cocke
  • Jenn A. Leiferman
  • Mary A. Steinhardt
  • Steven J. Schapiro
  • Pramod N. Nehete
  • Jaine E. Perlman
  • Jagannadha Sastry

There are no affiliations available

Personalised recommendations