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Journal of Bioenergetics and Biomembranes

, Volume 33, Issue 2, pp 127–134 | Cite as

Dietary Fat Type and Regular Exercise Affect Mitochondrial Composition and Function Depending on Specific Tissue in the Rat

  • José L. Quiles
  • Jesús R. Huertas
  • Mariano Mañas
  • Julio J. Ochoa
  • Maurizio Battino
  • José Mataix
Article

Abstract

Physical exercise and fatty acids have been studied in relation to mitochondrial composition and function in rat liver, heart, and skeletal muscle. Male rats were divided into two groups according to dietary fat type (virgin olive and sunflower oils). One-half of the animals from each group were subjected to a submaximal exercise for 8 weeks; the other half acted as sedentary controls. Coenzyme Q, cytochromes b, c + c1, a + a3 concentrations, and the activity of cytochrome c oxidase were determined. Regular exercise increased (P < 0.05) the concentration of the above-mentioned elements and the activity of the cytochrome c oxidase by roughly 50% in liver and skeletal muscle. In contrast, physical exercise decreased (P < 0.05) cytochrome c oxidase activity in the heart (in μmol/min/g, from 8.4 ± 0.1 to 4.9 ± 0.1 in virgin olive oil group and from 9.7 ± 0.1 to 6.7 ± 0.2 in sunflower oil animals). Dietary fat type raised the levels of coenzyme Q, cytochromes, and cytochrome c oxidase activity in skeletal muscle (P < 0.05) among the rats fed sunflower oil. In conclusion, dietary fat type, regular exercise, and the specific tissue modulate composition and function of rat mitochondria.

Virgin olive oil sunflower oil cytochrome c oxidase cytochromes coenzyme Q 

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Copyright information

© Plenum Publishing Corporation 2001

Authors and Affiliations

  • José L. Quiles
  • Jesús R. Huertas
  • Mariano Mañas
  • Julio J. Ochoa
  • Maurizio Battino
  • José Mataix

There are no affiliations available

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