Digestive Diseases and Sciences

, Volume 46, Issue 6, pp 1276–1284

Autonomic Nervous System Function in Women with Irritable Bowel Syndrome

  • Margaret Heitkemper
  • Monica Jarrett
  • Kevin C. Cain
  • Robert Burr
  • Rona L. Levy
  • Andrew Feld
  • Vicky Hertig
Article

Abstract

Autonomic nervous system (ANS) balance was assessed in women with and without irritable bowel syndrome (IBS) using laboratory tests of function (ie, expiratory/inspiratory ratio, Valsalva, posture changes, and cold pressor) and spectral and nonspectral measures of heart rate variability (HRV). Women with (N = 103) and without IBS (N = 49) were recruited, interviewed, then completed a laboratory assessment and wore a 24-hr Holter monitor Analysis using the entire sample showed little difference between IBS and control women and between subgroups with IBS on either laboratory measures or 24-hr HRV measures. However, analysis restricted to those women with severe IBS symptoms showed quite pronounced differences between two IBS subgroups on 24-hr HRV measures. Parasympathetic tone was significantly lower and ANS balance was significantly higher in the constipation-predominant compared to the diarrhea-predominant group. Subgroups of women with IBS do differ in ANS function as measured by 24-hr HRV; however, these differences are only apparent among women with severe symptoms. These findings point out the importance of considering symptom severity when interpreting studies of IBS.

autonomic nervous system irritable bowel syndrome women heart rate variability 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Copyright information

© Plenum Publishing Corporation 2001

Authors and Affiliations

  • Margaret Heitkemper
    • 1
  • Monica Jarrett
    • 1
  • Kevin C. Cain
    • 2
  • Robert Burr
    • 1
  • Rona L. Levy
    • 3
  • Andrew Feld
    • 4
  • Vicky Hertig
    • 1
  1. 1.Department of Biobehavioral Nursing and Health SystemsUniversity of WashingtonSeattle
  2. 2.Department of Biostatistics and Office of Nursing ResearchUniversity of WashingtonSeattle
  3. 3.School of Social WorkUniversity of WashingtonSeattle
  4. 4.Division of GastroenterologyUniversity of WashingtonSeattle

Personalised recommendations