Digestive Diseases and Sciences

, Volume 46, Issue 8, pp 1748–1756 | Cite as

A Spontaneous Nitric Oxide Donor Ameliorates Small Bowel Ischemia–Reperfusion Injury in Dogs

  • Kiyoshi Kawata
  • Izumi Takeyoshi
  • Kotaro Iwanami
  • Yutaka Sunose
  • Masaaki Aiba
  • Susumu Ohwada
  • Koshi Matsumoto
  • Yasuo Morishita


Nitric oxide (NO) appears to play an important role in tissue injury during reperfusion. FK409 is the first spontaneous NO donor that increases plasma guanosine 3`,5`-cyclic monophosphate. We investigated the effects of the NO donor FK409 (FK) on ischemia–reperfusion injury in a canine warm ischemia model. Fourteen adult mongrel dogs were divided into two groups: the control group and the FK group, which received FK. The superior mesenteric artery and vein were both clamped for 2 h and then reperfused for 12 h. Arterial and intramucosal pH were well maintained in the FK group in comparison with the control group. Histologically, ischemia–reperfusion injury was significantly more severe in the control group than in the FK group. The serum NO levels were significantly higher in the FK group than in the control group during FK administration. FK409 has protective effects on ischemia–reperfusion injury of the small intestine due to NO release.

small intestine ischemia–reperfusion injury, nitric oxide FK409 intramucosal pH 


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Copyright information

© Plenum Publishing Corporation 2001

Authors and Affiliations

  • Kiyoshi Kawata
    • 1
  • Izumi Takeyoshi
    • 1
  • Kotaro Iwanami
    • 1
  • Yutaka Sunose
    • 1
  • Masaaki Aiba
    • 1
  • Susumu Ohwada
    • 1
  • Koshi Matsumoto
    • 2
  • Yasuo Morishita
    • 1
  1. 1.Second Department of SurgeryGunma University School of MedicineMaebashiJapan
  2. 2.Department of PathologyNippon Medical SchoolKawasakiJapan

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