Digestive Diseases and Sciences

, Volume 46, Issue 7, pp 1540–1549

Symptoms Associated with Gastroesophageal Reflux Disease

  • Margaret Rothman
  • Christina Farup
  • Walter Stewart
  • Lawrence Helbers
  • Jerome Zeldis
Article

DOI: 10.1023/A:1010660425522

Cite this article as:
Rothman, M., Farup, C., Stewart, W. et al. Dig Dis Sci (2001) 46: 1540. doi:10.1023/A:1010660425522

Abstract

Many persons who suffer from GERD report additional symptoms, e.g., chest pain, dyspepsia, dysphagia, that are often not measured in clinical trials even though they may be distressing to the GERD sufferer. The primary goal of this study was to develop and assess the psychometric characteristics of a new GERD symptom scale measuring frequency, severity, and distress. The GERD Symptom Assessment Scale (GSAS) was administered to a sample of 169 GERD sufferers at baseline and two weeks. Internal consistency, construct validity, and test–retest reliability were assessed. Responsiveness was evaluated using clinical trial data assessing drug efficacy. Results: Internal consistency was >0.80 for the symptom severity and distress scales. All three scales showed stability over two weeks (ICC >0.70). Both validity hypotheses were supported. Comparison of effect sizes showed the GSAS is sensitive to changes in severity of symptoms. In conclusion, the GSAS is a reliable, valid, and responsive measure of GERD symptoms.

gastroesophageal reflux disease symptom assessment validity 

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Copyright information

© Plenum Publishing Corporation 2001

Authors and Affiliations

  • Margaret Rothman
    • 1
  • Christina Farup
    • 2
  • Walter Stewart
    • 3
  • Lawrence Helbers
    • 4
  • Jerome Zeldis
    • 5
  1. 1.Janssen Research FoundationTitusville
  2. 2.Janssen Pharmaceutica, Inc.Titusville
  3. 3.Innovative Medical Research, Inc.Towson
  4. 4.IBAHBlue Bell
  5. 5.Celgene CorporationWarren

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