Digestive Diseases and Sciences

, Volume 46, Issue 7, pp 1482–1489 | Cite as

Sulfated Polysaccharides, but Not Cellulose, Increase Colonic Mucus in Rats with Loperamide-Induced Constipation

  • Akira Shimotoyodome
  • Shinichi Meguro
  • Tadashi Hase
  • Ichiro Tokimitsu
  • Takashi Sakata


Colonic mucus is decreased in a rat model of spastic constipation, and some types of water-insoluble dietary fiber increase colonic mucus when consumed by rats for several weeks. However, little is known about the effect of water-soluble dietary fiber on the colonic mucus. The aim of the present study was to investigate the effect of various types of water-soluble dietary fiber on colonic mucus in a rat model of spastic constipation. Oral administration of 1.5 mg/day of carrageenan and chondroitin sulfate increased the fecal excretion, epithelial mucin production, thickness of the mucous layer, and amount of luminal mucus in loperamide-administered rats. Sodium alginate, 5 mg/day, thickened the mucus layer at the fecal surface. Cellulose, 5 mg/day, increased the fecal excretion but not the colonic mucus. Carrageenan, chondroitin sulfate, and sodium alginate, but not cellulose, increased colonic mucus in the rat model of spastic constipation.

carrageenan cellulose chondroitin sulfate colonic mucus dietary fiber loperamide 


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Copyright information

© Plenum Publishing Corporation 2001

Authors and Affiliations

  • Akira Shimotoyodome
    • 1
  • Shinichi Meguro
    • 1
  • Tadashi Hase
    • 1
  • Ichiro Tokimitsu
    • 1
  • Takashi Sakata
    • 2
  1. 1.Biological Science LaboratoriesKao CorporationTochigiJapan
  2. 2.Department of Basic SciencesIshinomaki Senshu UniversityMiyagiJapan

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