Journal of Neuro-Oncology

, Volume 51, Issue 2, pp 159–165 | Cite as

Neurophysiological Evaluation of Late Effects of Adjuvant High-dose Chemotherapy on Cognitive Function

  • Sanne B. Schagen
  • Hans L. Hamburger
  • Martin J. Muller
  • Willem Boogerd
  • Frits S.A.M. van Dam


Objectives: To evaluate late neurotoxicity of adjuvant high-dose (HD) chemotherapy versus standard-dose (SD) chemotherapy by event-related potentials (ERP) and quantitative electroencephalography (qEEG).

Patients and methods: From a randomized study in high-risk breast cancer patients on the efficacy of high-dose versus standard-dose adjuvant chemotherapy, late effects on cognitive functioning were analyzed by neuropsychological tests. Cognitive impairment was found in 32% of the HD group, 17% of the SD group and in 9% of a control group of stage I breast cancer patients not treated with chemotherapy. In 17 consecutive patients in the HD group and 16 consecutive patients in the SD group neurophysiological tests were performed, consisting of P300 and qEEG. Results of patients treated with chemotherapy were compared with results of 14 control patients not treated with chemotherapy. All patients were tested two years after treatment.

Results: Asymmetry of the alpha rhythm of ≥0.5 Hz was found in 7 HD patients, 2 SD patients and in none of the control patients (p = 0.01). No differences were found between the groups with regard to frequency of alpha rhythm, alpha blocking and latency of P300. No correlation was found between neurophysiological parameters and neuropsychological performance, except for an overall relation between the P300 latencies and the total number of deviant test scores.

Conclusion: Although the neurophysiological differences are subtle and the relation with the cognitive functioning in individual patients as measured by the neuropsychological examination is equivocal, the results suggest that there is neurophysiological support for cognitive dysfunction as a late complication of high-dose systemic chemotherapy in breast cancer.

breast cancer chemotherapy cognitive impairment ERP late effects qEEG 


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Copyright information

© Kluwer Academic Publishers 2001

Authors and Affiliations

  • Sanne B. Schagen
    • 1
  • Hans L. Hamburger
    • 2
  • Martin J. Muller
    • 1
  • Willem Boogerd
    • 2
    • 3
  • Frits S.A.M. van Dam
    • 4
    • 5
  1. 1.Department of Psychosocial research and EpidemiologyThe Netherlands Cancer Institute/Antoni van Leeuwenhoek HospitalNetherlands
  2. 2.Department of Neurology and Clinical NeurophysiologyMunicipal Hospital SlotervaartThe Netherlands
  3. 3.Department of Neuro-OncologyThe Netherlands Cancer Institute/Antoni van Leeuwenhoek HospitalThe Netherlands
  4. 4.Department of Psychosocial research and EpidemiologyThe Netherlands Cancer Institute/Antoni van Leeuwenhoek HospitalThe Netherlands
  5. 5.Department of Clinical PsychologyUniversity of AmsterdamAmsterdamThe Netherlands

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