Journal of Neuro-Oncology

, Volume 51, Issue 3, pp 219–229 | Cite as

The INK4A/ARF Locus: Role in Cell Cycle Control and Apoptosis and Implications for Glioma Growth

  • Stacey M. Ivanchuk
  • Soma Mondal
  • Peter B. Dirks
  • James T. Rutka


The unique INK4A/ARF locus at chromosome 9p21 encodes two distinct proteins that intimately link the pRB and p53 tumour suppressor pathways. p16INK4A has been identified as an inhibitor of the cell cycle, capable of inducing arrest in G1 phase. p14/p19ARF on the other hand can induce both G1 and G2 arrest due to its stabilizing effects on the p53 transcription factor. In addition to their roles in growth arrest, both proteins are involved in cellular senescence and apoptosis. The frequent mutation or deletion of INK4A/ARF in human tumours as well as the occurence of tumours in the murine knockout models have identified both p16 and ARF as bona fide tumour suppressors.

apoptosis growth arrest INK4A/ARF p53 pRB tumour suppressor 


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Copyright information

© Kluwer Academic Publishers 2001

Authors and Affiliations

  • Stacey M. Ivanchuk
    • 1
  • Soma Mondal
    • 1
  • Peter B. Dirks
    • 1
  • James T. Rutka
    • 1
  1. 1.Division of Neurosurgery and The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick ChildrenUniversity of TorontoTorontoCanada

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