Journal of Behavioral Medicine

, Volume 24, Issue 4, pp 323–339 | Cite as

Perceived Stress and Cellular Immunity: When Coping Counts

  • Jeffrey R. Stowell
  • Janice K. Kiecolt-Glaser
  • Ronald Glaser


This cross-sectional study investigated whether active and avoidance coping methods were differentially related to immune function depending on stress level. Perceived stress and coping method were assessed in 173 healthy older adults and related to the number and percentage of CD3+, CD4+, and CD8+ T lymphocytes as well as the proliferative response of peripheral blood leukocytes to phytohemagluttinin (PHA) and concanavalin A (Con A). Both active and avoidance coping significantly interacted with perceived stress on proliferative responses to both mitogens. Higher levels of active coping were significantly related to a more vigorous proliferative response to PHA and Con A, particularly at high stress levels. At low stress levels, active coping was not significantly related to proliferative responses, whereas avoidance coping was significantly associated with a greater proliferative response to Con A. These results suggest that the relationships between certain coping methods and immune function depend on perceived stress level.

psychoneuroimmunology psychoimmunology avoidance aging 


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  1. Aiken, L. S., and West, S. G. (1991). In West, S. G., and Reno, R. R. (Eds.), Multiple Regression: Testing and Interpreting Interactions, Sage, Newbury Park, CA, 212 pp.Google Scholar
  2. Aldwin, C. M., Revenson, T. A. (1987). Does coping help? A reexamination of the relation between coping and mental health. J. Pers. Soc. Psychol. 53(2): 337-348.Google Scholar
  3. Bender, B. S., Nagel, J. E., Adler, W. H., and Andres, R. (1986). Absolute peripheral blood lymphocyte count and subsequent mortality of elderly men. The Baltimore Longitudinal Study of Aging. J. Am. Geriatr. Soc. 34(9): 649-654.Google Scholar
  4. Billings, A. G., and Moos, R. H. (1981). The role of coping responses and social resources in attenuating the stress of life events. J. Behav. Med. 4(2): 139-157.Google Scholar
  5. Bodnar, J. C., and Kiecolt-Glaser, J. K. (1994). Caregiver depression after bereavement: Chronic stress isn't over when it's over. Psychol. Aging 9(3): 372-380.Google Scholar
  6. Brosschot, J. F., Godaert, G. L., Benschop, R. J., Olff, M., Ballieux, R. E., and Heijnen, C. J. (1998). Experimental stress and immunological reactivity: A closer look at perceived uncontrollability. Psychosom. Med. 60(3): 359-361.Google Scholar
  7. Carver, C. S., Pozo, C., Harris, S. D., Noriega, V., Scheier, M. F., Robinson, D. S., Ketcham, A. S., Moffat, F. L., and Clark, K. C., Jr. (1993). How coping mediates the effect of optimism on distress: A study of women with early stage breast cancer. J. Pers. Soc. Psychol. 65(2): 375-390.Google Scholar
  8. Carver, C. S., and Scheier, M. F. (1994). Situational coping and coping dispositions in a stressful transaction. J. Pers. Soc. Psychol. 66(1): 184-195.Google Scholar
  9. Carver, C. S., Scheier, M. F., and Weintraub, J. K. (1989). Assessing coping strategies: A theoretically based approach. J. Pers. Soc. Psychol. 56(2): 267-283.Google Scholar
  10. Cohen, D., and Eisdorfer, C. (1988). Depression in family members caring for a relative with Alzheimer's disease. J. Am. Geriatr. Soc. 36(10): 885-889.Google Scholar
  11. Cohen, S., and Williamson, G. M. (1988). Perceived stress in a probability sample of the United States. In Spacapan, S., and Oskamp, S. (Eds.) The Social Psychology of Health, Sage, Beverly Hills, CA, pp. 31-67.Google Scholar
  12. Compas, B. E., Worsham, N. L., Ey, S., and Howell, D. C. (1996). When mom or dad has cancer: II. Coping, cognitive appraisals, and psychological distress in children of cancer patients. Health Psychol. 15(3): 167-175.Google Scholar
  13. Dura, J. R., Stukenberg, K. W., and Kiecolt-Glaser, J. K. (1990). Chronic stress and depressive disorders in older adults. J. Abnorm. Psychol. 99(3): 284-290.Google Scholar
  14. Esterling, B. A., Antoni, M. H., Kumar, M., and Schneiderman, N. (1993). Defensiveness, trait anxiety, and Epstein-Barr viral capsid antigen antibody titers in healthy college students. Health Psychol. 12(2): 132-139.Google Scholar
  15. Esterling, B. A., Kiecolt-Glaser, J. K., and Glaser, R. (1996). Psychosocial modulation of cytokine-induced natural killer cell activity in older adults. Psychosom. Med. 58(3): 264-272.Google Scholar
  16. Finney, J. W., Mitchell, R. E., Cronkite, R. C., Moos, R. H. (1984). Methodological issues in estimating main and interactive effects: Examples from coping/social support and stress field. J. Health Soc. Behav. 25(1): 85-98.Google Scholar
  17. Folkman, S., and Lazarus, R. S. (1980). An analysis of coping in a middle-aged community sample. J. Health Soc. Behav. 21(3): 219-239.Google Scholar
  18. Folkman, S., and Lazarus, R. S. (1986). Stress-processes and depressive symptomatology. J. Abnorm. Psychol. 95(2): 107-113.Google Scholar
  19. Genco, R. J., Ho, A. W., Grossi, S. G., Dunford, R. G., and Tedesco, L. A. (1999). Relationship of stress, distress and inadequate coping behaviors to periodontal disease. J. Periodontol. 70(7): 711-723.Google Scholar
  20. Goodkin, K., Blaney, N. T., Feaster, D., Fletcher, M. A., Baum, M. K., Mantero-Atienza, E., Klimas, N. G., Millon, C., Szapocznik, J., and Eisdorfer, C. (1992a). Active coping style is associated with natural killer cell cytotoxicity in asymptomatic HIV-1 seropositive homosexual men. J. Psychosom. Res. 36(7): 635-650.Google Scholar
  21. Goodkin, K., Feaster, D. J., Tuttle, R., Blaney, N. T., Kumar, M., Baum, M. K., Shapshak, P., and Fletcher, M. A. (1996). Bereavement is associated with time-dependent decrements in cellular immune function in asymptomatic human immunodeficiency virus type 1-seropositive homosexual men. Clin. Diagn. Lab. Immunol. 3(1): 109-118.Google Scholar
  22. Goodkin, K., Fuchs, I., Feaster, D., Leeka, J., and Rishel, D. D. (1992b). Life stressors and coping style are associated with immune measures in HIV-1 infection-a preliminary report. Int. J. Psychiatry Med. 22(2): 155-172.Google Scholar
  23. Heckler, M. M. (1985). The fight against Alzheimer's disease. Am Psychol 40(11): 1240-1244.Google Scholar
  24. Heston, L. L., Mastri, A. R., Anderson, V. E., and White, J. (1981). Dementia of the Alzheimer type. Clinical genetics, natural history, and associated conditions. Arch. Gen. Psychiatry 38(10): 1085-1090.Google Scholar
  25. Holahan, C. J., and Moos, R. H. (1987). Personal and contextual determinants of coping strategies. J. Pers. Soc. Psychol. 52(5): 946-955.Google Scholar
  26. Ingledew, D. K., Hardy, L., and Cooper, C. L. (1997). Do resources bolster coping and does coping buffer stress? An organizational study with longitudinal aspect and control for negative affectivity. J. Occup. Health Psychol. 2(2): 118-133.Google Scholar
  27. Kiecolt-Glaser, J. K., Dura, J. R., Speicher, C. E., Trask, O. J., and Glaser, R. (1991). Spousal caregivers of dementia victims: Longitudinal changes in immunity and health. Psychosom. Med. 53(4): 345-362.Google Scholar
  28. Kiecolt-Glaser, J. K., and Glaser,R. (1995). Psychoneuroimmunology and health consequences: Data and shared mechanisms. Psychosom. Med. 57(3): 269-274.Google Scholar
  29. Lackner, J. B., Joseph, J. G., Ostrow, D. G., Kessler, R. C., Eshleman, S., Wortman, C. B., O'Brien, K, Phair, J. P., and Chmiel, J. (1993). A longitudinal study of psychological distress in a cohort of gay men. Effects of social support and coping strategies. J. Nerv. Ment. Dis. 181(1): 4-12.Google Scholar
  30. Laudenslager, M. L., Ryan, S. M., Drugan, R. C., Hyson, R. L., and Maier, S. F. (1983). Coping and immunosuppression: Inescapable but not escapable shock suppresses lymphocyte proliferation. Science 221(4610): 568-570.Google Scholar
  31. Lazarus, R. S., and Folkman, S. Stress, Appraisal, and Coping, Springer, NewYork, 1984. 445 pp.Google Scholar
  32. McNaughton, M. E., Smith, L. W., Patterson, T. L., and Grant, I. (1990). Stress, social support, coping resources, and immune status in elderly women. J. Nerv. Ment. Dis. 178(7): 460-461.Google Scholar
  33. McQueeney, D. A., Stanton, A. L., and Sigmon, S. (1997). Efficacy of emotion-focused and problem-focused group therapies for women with fertility problems. J. Behav. Med. 20(4): 313-331.Google Scholar
  34. Molassiotis, A., Van Den Akker, O. B., Milligan, D. W., and Goldman, J. M. (1997). Symptom distress, coping style and biological variables as predictors of survival after bone marrow transplantation. J. Psychosom. Res. 42(3): 275-285.Google Scholar
  35. Murasko, D. M., Gold, M. J., Hessen, M. T., and Kaye, D. (1990). Immune reactivity, morbidity, and mortality of elderly humans. Aging Immunol. Infect. Dis. 2(3): 171-180.Google Scholar
  36. Murasko, D. M., Weiner, P., and Kaye, D. (1987). Decline in mitogen induced proliferation of lymphocytes with increasing age. Clin. Exp. Immunol. 70(2): 440-448.Google Scholar
  37. Nakano, K. (1991). Coping strategies and psychological symptoms in a Japanese sample. J. Clin. Psychol. 47(3): 346-350.Google Scholar
  38. Ntoumanis, N., and Biddle, S. J. H. (1998). The relationship of coping and its perceived effectiveness to positive and negative affect in sport. Pers. Indiv. Differ. 24(6): 773-788.Google Scholar
  39. Nyamathi, A., Jacoby, A., Constancia, P., and Ruvevich, S. (1992). Coping and adjustment of spouses of critically ill patients with cardiac disease. Heart Lung 21(2): 160-166.Google Scholar
  40. Redinbaugh, E. M., MacCallum, R. C., and Kiecolt-Glaser, J. K. (1995). Recurrent syndromal depression in caregivers. Psychol. Aging 10(3): 358-368.Google Scholar
  41. Reynaert, C., Janne, P., Bosly, A., Staquet, P., Zdanowicz, N., Vause, M., Chatelain, B., and Lejeune, D. (1995). From health locus of control to immune control: Internal locus of control has a buffering effect on natural killer cell activity decrease in major depression. Acta Psychiatr. Scand. 92(4): 294-300.Google Scholar
  42. Segerstrom, S. C., Taylor, S. E., Kemeny, M. E., and Fahey, J. L. (1998). Optimism is associated with mood, coping, and immune change in response to stress. J. Pers. Soc. Psychol. 74(6): 1646-1655.Google Scholar
  43. Stanton, A. L., and Snider, P. R. (1993). Coping with a breast cancer diagnosis: A prospective study. Health Psychol. 12(1): 16-23.Google Scholar
  44. Stephens, M. A., Norris, V. K., Kinney, J. M., Ritchie, S. W., and Grotz, R. C. (1988). Stressful situations in caregiving: Relations between caregiver coping and well-being. Psychol. Aging 3(2): 208-209.Google Scholar
  45. Swindells, S., Mohr, J., Justis, J. C., Berman, S., Squier, C., Wagener, M. M., and Singh, N. (1999). Quality of life in patients with human immunodeficiency virus infection: Impact of social support, coping style and hopelessness. Int. J. STD AIDS 10(6): 383-391.Google Scholar
  46. Wayne, S. J., Rhyne, R. L., Garry, P. J., and Goodwin, J. S. (1990). Cell-mediated immunity as a predictor of morbidity and mortality in subjects over 60. J. Gerontol. 45(2): M45-M48.Google Scholar
  47. Zautra, A. J., Okun, M. A., Robinson, S. E., Lee, D., Roth, S. H., and Emmanual, J. (1989). Life stress and lymphocyte alterations among patients with rheumatoid arthritis. Health Psychol. 8(1): 1-14.Google Scholar

Copyright information

© Plenum Publishing Corporation 2001

Authors and Affiliations

  • Jeffrey R. Stowell
  • Janice K. Kiecolt-Glaser
  • Ronald Glaser

There are no affiliations available

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