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Biotechnology Letters

, Volume 23, Issue 13, pp 1051–1056 | Cite as

Two useful dimensionless parameters that combine physiological, operational and bioreactor design parameters for improved control of dissolved oxygen

  • A. De León
  • A.P. Barba-de la Rosa
  • H. Mayani
  • E. Galindo
  • O.T. Ramírez
Article

Abstract

Two new dimensionless parameters (Φ and Ω) are proposed for calculating the proportional, integral, and derivative constants of a dissolved oxygen proportional integral-derivative (PID) feed-back control algorithm from knowledge of the growth rate, bioreactor design and operation variables. The values of Φ and Ω were determined for a broad range of Reynolds numbers (between 1000 to 40 000) during the exponential growth phase of two highly different processes: fermentations of recombinant Escherichia coli and cultures of human hematopoietic cells. The utility of Φ and Ω for use in dissolved oxygen self-tunning adaptive control algorithms is discussed.

bioreactor dimensionless numbers dissolved oxygen hematopoietic cells PID controller recombinant E. coli 

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Copyright information

© Kluwer Academic Publishers 2001

Authors and Affiliations

  • A. De León
    • 1
  • A.P. Barba-de la Rosa
    • 1
  • H. Mayani
    • 2
  • E. Galindo
    • 3
  • O.T. Ramírez
    • 3
  1. 1.Depto. de Ingeniería Bioquímica, Av. Tecnológico y García Cubas s/nInstituto Tecnológico de CelayaCelayaMéxico
  2. 2.Hospital de OncologíaCentro Médico Nacional Siglo XXIMéxicoMéxico
  3. 3.Instituto de Biotecnología, Depto. de BioingenieríaUniversidad Nacional Autónoma de MéxicoCuernavacaMéxico

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