Advertisement

Biochemistry (Moscow)

, Volume 66, Issue 5, pp 467–475 | Cite as

Role of Transcription Factor NFAT in the Immune Response

  • E. M. Kuklina
  • S. V. Shirshev
Article

Abstract

Molecular mechanisms of activation of nuclear factor NFAT in cells of the lympho-myeloid complex are considered. Members of the NFAT family regulate transcription of genes encoding proteins involved in the induction and/or regulation of the immune response. It is possible that altered transcription activity of NFAT under conditions of its deficit or blockade of expression may account for changes in the immune status of an organism.

NFAT immune response apoptosis lymphocytes macrophages mast cells cytokines 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

REFERENCES

  1. 1.
    Chow, C. W., Rincon, M., and Davis, R. J. (1999) Mol. Cell. Biol., 19, 2300–2307.Google Scholar
  2. 2.
    Ranger, A. M., Oukka, M., Rengarajan, J., and Glimcher, L. H. (1998) Immunity, 9, 627–635.Google Scholar
  3. 3.
    Xanthoudakis, S., Viola, J. P., Shaw, K. T., Luo, C., Wallace, J. D., Bozza, P. T., Luk, D. C., Curran, T., and Rao, A. (1996) Science, 272, 892–895.Google Scholar
  4. 4.
    Fuller, C. L., Ravichandran, K. S., and Brasiale, V. L. (1999) J. Immunol., 11, 6337–6340.Google Scholar
  5. 5.
    Mosmann, T. R., and Coffman, R. L. (1989) Annu. Rev. Immunol., 7, 145–173.Google Scholar
  6. 6.
    O'Garra, P., and Murphy, K. (1994) Curr. Opin. Immunol., 6, 458–466.Google Scholar
  7. 7.
    Freidlin, I. S. (1984) The System of Mononuclear Macrophages [in Russian], Meditsina, Moscow.Google Scholar
  8. 8.
    McCaffrey, P. G., Luo, C., Kerppola, T. K., Jain, J., Badalian, T. M., Ho, A. M., Burgeon, E., Lane, W. S., Lambert, J. N., and Curran, T. (1993) Science, 262, 750–754.Google Scholar
  9. 9.
    Masuda, E. S., Naito, Y., Tokumitsu, H., Campbell, D., Saito, F., Hannum, C., Arai, K., and Arai, N. (1995) Mol. Cell. Biol., 15, 2697–2706.Google Scholar
  10. 10.
    Ho, S. N., Thomas, D. J., Timmerman, L. A., Li, X., Francke, U., and Crabtree, G. R. (1995) J. Biol. Chem., 270, 19898–19907.Google Scholar
  11. 11.
    Northrop, J. P., Ho, S. N., Chen, L., Thomas, D. J., Timmerman, L. A., Nolan, G. P., Admon, A., and Crabtree, G. R. (1994) Nature, 369, 497–502.Google Scholar
  12. 12.
    Loez-Rodriguez, C., Aramburu, J., Rakeman, A. S., and Rao, A. (1999) Proc. Natl. Acad. Sci. USA, 96, 7214–7219.Google Scholar
  13. 13.
    Amasaki, Y., Masuda, E. S., Imamura, R., Arai, K.-I., and Arai, N. (1998) J. Immunol., 160, 2324–2333.Google Scholar
  14. 14.
    Choi, M. S., Brines, R. D., Holman, M. J., and Klaus, G. G. (1994) Immunity, 1, 179–187.Google Scholar
  15. 15.
    Loh, C., Carew, J. A., Kim, J., Hogan, P. G., and Rao, A. (1996) Mol. Cell. Biol., 16, 3945–3954.Google Scholar
  16. 16.
    Aramburu, J., Azzoni, L., Rao, A., and Perussia, B. (1995) J. Exp. Med., 182, 801–810.Google Scholar
  17. 17.
    Weiss, D. L., Hural, J., Tara, D., Timmerman, L. A., Henkel, J., and Brown, M. A. (1996) Mol. Cell. Biol., 16, 228–235.Google Scholar
  18. 18.
    Rao, A., Luo, C., and Hogan, P. G. (1997) Annu. Rev. Immunol., 15, 707–747.Google Scholar
  19. 19.
    Hoey, T., Sun, Y.-L., Williamson, K., and Xu, X. (1995) Immunity, 2, 461–472.Google Scholar
  20. 20.
    Hutchinson, L. E., and McCloskey, M. A. (1995) J. Biol. Chem., 270, 16333–16338.Google Scholar
  21. 21.
    Park, D. J., Rho, H. V., and Rhee, S. G. (1991) Proc. Natl. Acad. Sci. USA, 88, 5453–5461.Google Scholar
  22. 22.
    Altman, A., Coggeshall, M., and Mustelin, T. (1990) Adv. Immunol., 48, 227–236.Google Scholar
  23. 23.
    Harnick, D. J., Jayaraman, T., Ma, Y., Mulieri, P., Go, L. O., and Marks, A. R. (1995) J. Biol. Chem., 270, 2833–2840.Google Scholar
  24. 24.
    Loh, C., Shaw, K. T., Carew, J., Viola, J. P., Luo, C., Perrino, B. A., and Rao, A. (1996) J. Biol. Chem., 271, 10884–10891.Google Scholar
  25. 25.
    Luo, C., Burgeon, E., and Rao, A. (1996) J. Exp. Med., 184, 141–147.Google Scholar
  26. 26.
    Luo, C., Shaw, K. T., Raghavan, A., Aramburu, J., Garciacutea-Coacutezar, F., Perrino, B. A., Hogan, P. G., and Rao, A. (1996) Proc. Natl. Acad. Sci. USA, 93, 8907–8912.Google Scholar
  27. 27.
    Klee, C. B., Draetta, G. F., and Hubbard, M. (1988) J. Adv. Enzymol., 61, 149–200.Google Scholar
  28. 28.
    Sikkink, R., Haddy, A., MacKelvie, S., Mertz, P., Litwiller, R., and Rusnak, F. (1995) Biochemistry, 34, 8348–8356.Google Scholar
  29. 29.
    Hubbard, M. J., and Klee, C. B. (1989) Biochemistry, 28, 1868–1874.Google Scholar
  30. 30.
    Hashimoto, Y., Perrino, B. A., and Soderling, T. R. (1990) J. Biol. Chem., 265, 1924–1927.Google Scholar
  31. 31.
    Kissinger, C. R., Parge, H. E., Knighton, D. R., Lewis, C. T., Pelletier, L. A., Tempczyk, A., Kalish, V. J., Tucker, K. D., Showalter, R. E., and Moomaw, E. W. (1995) Nature, 378, 641–644.Google Scholar
  32. 32.
    Garcia-Cozar, F. J., Okamura, H., Aramburu, J. F., Shaw, K. T. Y., Pelletier, L., Showalter, R., Villafranca, E., and Rao, A. (1998) J. Biol. Chem., 273, 23877–23883.Google Scholar
  33. 33.
    Liu, J., Farmer, J. D., Jr., Lane, W. S., Friedman, J., Weissman, I., and Schreiber, S. L. (1991) Cell, 66, 807–815.Google Scholar
  34. 34.
    Shaw, K. T., Ho, A. M., Raghavan, A., Kim, J., Jain, J., Park, J., Sharma, S., Rao, A., and Hogan, P. G. (1995) Proc. Natl. Acad. Sci. USA, 92, 11205–11209.Google Scholar
  35. 35.
    Mattila, P. S., Ullman, K. S., Fiering, S., Emmel, E. A., McCutcheon, M., Crabtree, G. R., and Herzenberg, L. A. (1990) EMBO J., 9, 4425–4433.Google Scholar
  36. 36.
    Venkataraman, L., Francis, D. A., Wang, Z., Liu, J., Rothstein, T. L., and Sen, R. (1994) Immunity, 1, 189–196.Google Scholar
  37. 37.
    Chow, C. W., Rincon, M., Cavanagh, J., Dickens, M., and Davis, R. J. (1997) Science, 278, 1638–1641.Google Scholar
  38. 38.
    Chow, C. W., and Davis, R. J. (2000) Mol. Cell. Biol., 20, 702–712.Google Scholar
  39. 39.
    Jain, J., McCaffrey, P. G., Miner, Z., Kerppola, T. K., Lambert, J. N., Verdine, G. L., Curran, T., and Rao, A. (1993) Nature, 365, 352–355.Google Scholar
  40. 40.
    Yaseen, N. R., Maizel, A. L., Wang, F., and Sharma, S. (1993) J. Biol. Chem., 268, 14285–14293.Google Scholar
  41. 41.
    Genot, E., Cleverley, S., Henning, S., and Cantrell, D. (1996) EMBO J., 15, 3923–3933.Google Scholar
  42. 42.
    Sun, L. J., Peterson, B. R., and Verdine, G. L. (1997) Proc. Natl. Acad. Sci. USA, 94, 4919–4924.Google Scholar
  43. 43.
    Peterson, B. R., Sun, L. J., and Verdine, G. L. (1996) Proc. Natl. Acad. Sci. USA, 93, 13671–13676.Google Scholar
  44. 44.
    Jain, J., Miner, Z., and Rao, A. (1993) J. Immunol., 151, 837–848.Google Scholar
  45. 45.
    Georas, S. N., Cumberland, J. E., Burke, T. F., Chen, R., Schindler, U., and Casolaro, V. (1998) Blood, 92, 4529–4538.Google Scholar
  46. 46.
    Sweetser, M. T., Hoey, T., Sun, Y. L., Weaver, W. M., Price, G. A., and Wilson, C. B. (1998) J. Biol. Chem., 273, 34775–34783.Google Scholar
  47. 47.
    Tsai, E. Y., Yie, J., Thanos, D., and Goldfeld, A. E. (1996) Mol. Cell. Biol., 16, 5232–5244.Google Scholar
  48. 48.
    Holtz-Heppelmann, C. J., Algeciras, A., Badley, A. D., and Paya, C. V. (1998) J. Biol. Chem., 273, 4416–4423.Google Scholar
  49. 49.
    Rooney, J. W., Sun, Y. L., Glimcher, L. H., and Hoey, T. (1995) Mol. Cell. Biol., 11, 6299–6310.Google Scholar
  50. 50.
    Li-Weber, M., Salgame, P., Hu C., and Krammer, P. H. (1997) Gene, 188, 253–260.Google Scholar
  51. 51.
    Burke, T. F., Casolaro, V., and Georas, S. N. (2000) Biochem. Biophys. Res. Commun., 270, 1016–1023.Google Scholar
  52. 52.
    Viola, P. B., Kiani, A., Bozza, P. T., and Rao, A. (1998) Blood, 7, 2223–2230.Google Scholar
  53. 53.
    Kiani, A., Viola, J. P., Lichtman, A. H., and Rao, A. (1997) Immunity, 7, 849–860.Google Scholar
  54. 54.
    Sica, A., Dorman, L., Viggiano, V., Cippitelli, M., Ghosh, P., Rice, N., and Young, H. A. (1997) J. Biol. Chem., 272, 30412–30420.Google Scholar
  55. 55.
    Cockerill, P. N., Shannon, M. F., Bert, A. G., Ryan, G. R., and Vadas, M. A. (1993) Proc. Natl. Acad. Sci. USA, 90, 2466–2470.Google Scholar
  56. 56.
    Nair, A. P., Hahn, S., Banholzer, R., Hirsch, H. H., and Moroni, C. (1994) Nature, 369, 239–942.Google Scholar
  57. 57.
    Shannon, M. F., Coles, L. S., Vadas, M. A., and Cockerill, P. N. (1997) Crit. Rev. Immunol., 17, 301–323.Google Scholar
  58. 58.
    Feske, S., Draeger, R., Peter, H. H., Eichmann, K., and Rao, A. (2000) J. Immunol., 165, 297–305.Google Scholar
  59. 59.
    Tsitsikov, E. N., Ramesh, N., and Geha, R. S. (1994) Mol. Immunol., 31, 895–900.Google Scholar
  60. 60.
    Latinis, K. M., Carr, L. L., Peterson, E. J., Norian, L. A., Eliason, S. L., and Koretzky, G. A. (1997) J. Immunol., 158, 4602–4611.Google Scholar
  61. 61.
    Brunner, T., Yoo, N. J., LaFace, D., Ware, C. F., and Green, D. R. (1996) Int. Immunol., 8, 1017–1026.Google Scholar
  62. 62.
    Hodge, M. R., Ranger, A. M., de la Brousse, F. C., Hoey, T., Grusby, M. J., and Glimcher, L. H. (1996) Immunity, 4, 397–405.Google Scholar
  63. 63.
    Latinis, K. M., Norian, L. A., Eliason, S. L., and Koretzky, G. A. (1997) J. Biol. Chem., 272, 31427–31434.Google Scholar
  64. 64.
    Cron, R. Q., Bartz, S. R., Clausell, A., Bort, S. J., Klebanoff, S. J., and Lewis, D. B. (2000) Clin. Immunol., 94, 179–191.Google Scholar
  65. 65.
    Bassuk, A. G., Anandappa, R. T., and Leiden, J. M. (1997) J. Virol., 71, 3563–3573.Google Scholar
  66. 66.
    Macian, F., and Rao, A. (1999) Mol. Cell. Biol., 19, 3645–3653.Google Scholar
  67. 67.
    Morris, P. J. (1981) Transplantation, 32, 349–354.Google Scholar
  68. 68.
    Ranger, A. M., Hodge, M. R., Gravallese, E. M., Oukka, M., Davidson, L., Alt, F. W., de la Brousse, F. C., Hoey, T., Grusby, M., and Glimcher, L. H. (1998) Immunity, 8, 125–134.Google Scholar
  69. 69.
    Yoshida, H., Nishina, H., Takimoto, H., Marengere, L. E., Wakeham, A. C., Bouchard, D., Kong, Y.-Y., Ohteki, T., Shahinian, A., Bachmann, M., Ohashi, P. S., Penninger, J. M., Crabtree, G. R., and Mak, T. W. (1998) Immunity, 8, 115–124.Google Scholar
  70. 70.
    Noel, P. J., Boise, L. H., Green, J. M., and Thompson, C. B. (1996) J. Immunol., 157, 636–642.Google Scholar
  71. 71.
    Radvanyi, L. G., Shi, Y., Vaziri, H., Sharma, A., Dhala, R., Mills, G. B., and Miller, R. G. (1996) J. Immunol., 156, 1788–1798.Google Scholar
  72. 72.
    Oukka, M., Ho, I.-C., de la Brousse, F., Hoey, T., Grusby, M. J., and Glimcher, L. H. (1998) Immunity, 9, 295–304.Google Scholar
  73. 73.
    Fraser, J. H., Rincon, M., McCoy, K. D., and le Gros, G. (1999) Eur. J. Immunol., 29, 838–844.Google Scholar
  74. 74.
    Miyajima, A., Kitamura, T., Harada, N., Yokota, T., and Arai, K.-J. (1992) Annu. Rev. Immunol., 10, 295–331.Google Scholar
  75. 75.
    Gleich, G. L., and Kita, H. (1997) Proc. Natl. Acad. Sci. USA, 94, 2101–2106.Google Scholar
  76. 76.
    Desreumaux, P., and Capron, M. (1996) Curr. Opin. Immunol., 8, 790–796.Google Scholar

Copyright information

© MAIK “Nauka/Interperiodica” 2001

Authors and Affiliations

  • E. M. Kuklina
    • 1
  • S. V. Shirshev
    • 1
  1. 1.Institute of Ecology and Genetics of Microorganisms, Ural DivisionRussian Academy of SciencesPermRussia

Personalised recommendations