Biochemistry (Moscow)

, Volume 66, Issue 5, pp 467–475 | Cite as

Role of Transcription Factor NFAT in the Immune Response

  • E. M. Kuklina
  • S. V. Shirshev


Molecular mechanisms of activation of nuclear factor NFAT in cells of the lympho-myeloid complex are considered. Members of the NFAT family regulate transcription of genes encoding proteins involved in the induction and/or regulation of the immune response. It is possible that altered transcription activity of NFAT under conditions of its deficit or blockade of expression may account for changes in the immune status of an organism.

NFAT immune response apoptosis lymphocytes macrophages mast cells cytokines 


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Copyright information

© MAIK “Nauka/Interperiodica” 2001

Authors and Affiliations

  • E. M. Kuklina
    • 1
  • S. V. Shirshev
    • 1
  1. 1.Institute of Ecology and Genetics of Microorganisms, Ural DivisionRussian Academy of SciencesPermRussia

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