Biochemistry (Moscow)

, Volume 66, Issue 7, pp 703–714

Proteinase Inhibitors from the Medicinal Leech Hirudo medicinalis

  • I. P. Baskova
  • L. L. Zavalova
Article

Abstract

The medicinal leech Hirudo medicinalis produces various types of proteinase inhibitors: bdellins (inhibitors of trypsin, plasmin, and acrosin), hirustasin (inhibitor of tissue kallikrein, trypsin, α-chymotrypsin, and granulocyte cathepsin G), tryptase inhibitor, eglins (inhibitors of α-chymotrypsin, subtilisin, and chymasin and the granulocyte proteinases elastase and cathepsin G), inhibitor of factor Xa, hirudin (thrombin inhibitor), inhibitor of carboxypeptidase, and inhibitor of complement component C1s. This review summarizes data on their primary and tertiary structures, action mechanisms, and biological activities.

medicinal leech bdellins eglins hirustasin tryptase inhibitor factor Xa inhibitor hirudin carboxypeptidase inhibitor component complement inhibitor trypsin chymotrypsin thrombin kallikrein subtilisin granulocyte elastase granulocyte cathepsin G 

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Copyright information

© MAIK “Nauka/Interperiodica” 2001

Authors and Affiliations

  • I. P. Baskova
    • 1
  • L. L. Zavalova
    • 2
  1. 1.School of BiologyLomonosov Moscow State UniversityMoscowRussia
  2. 2.Shemyakin and Ovchinnikov Institute of Bioorganic ChemistryRussian Academy of SciencesMoscowRussia

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